This scoping review examines peer-reviewed literature of governance and public engagement at the intersection of public health and climate change in South America. The review shows significant gaps in academic publications, particularly because health was mostly a secondary theme examined in the studies. The few studies about governmental interventions (e.g., policies and programs) suggest that these have not been effective. Regarding public engagement, no studies examined social media engagement with health and climate change, and only one examined news coverage. Finally, most articles focused primarily on individual countries, with few comparative or regional analyses of South America. Strategic action addressing climate change and its effects on public health needs to be based on empirical evidence.