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Comprehensive review of ST-segment elevation myocardial infarction: Understanding pathophysiology, diagnostic strategies, and current treatment approaches

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dc.contributor.author Elendu, Chukwuka
dc.contributor.author Amaechi, Dependable C.
dc.contributor.author Elendu, Tochi C.
dc.contributor.author Omeludike, Eunice K.
dc.contributor.author Alakwe-Ojimba, Chisom E.
dc.contributor.author Obidigbo, Babajide
dc.contributor.author Akpovona, Otite L.
dc.contributor.author Oros Sucari, Yuliana Paola
dc.contributor.author Saggi, Sehajmeet Kaur
dc.contributor.author Dang, Kanishk
dc.contributor.author Chinedu, Chinedu P.
dc.date.accessioned 2023-12-05T17:47:58Z
dc.date.available 2023-12-05T17:47:58Z
dc.date.issued 2023
dc.identifier.uri https://hdl.handle.net/20.500.12866/14619
dc.description.abstract ST-Segment Elevation Myocardial Infarction (STEMI) is a life-threatening medical emergency characterized by complete coronary artery occlusion, leading to myocardial ischemia and subsequent necrosis. Over the years, STEMI has remained a significant cause of morbidity and mortality worldwide, necessitating a comprehensive understanding of its pathophysiology, accurate diagnostic strategies, and effective treatment approaches. This review article aims to thoroughly analyze the current knowledge surrounding STEMI, emphasizing key aspects crucial for optimizing patient outcomes. Firstly, the pathophysiology of STEMI will be explored, elucidating the sequence of events from coronary artery plaque rupture to thrombus formation and occlusion. This section will also cover the underlying risk factors contributing to STEMI development, including atherosclerosis, hypertension, and diabetes. Secondly, the diagnostic modalities for STEMI will be critically evaluated. Traditional electrocardiography remains the cornerstone of STEMI diagnosis. Still, advancements in imaging techniques such as cardiac magnetic resonance imaging and coronary angiography have enhanced accuracy and allow for better risk stratification. Furthermore, the review will delve into the latest treatment approaches for STEMI. Prompt reperfusion therapy through primary percutaneous coronary intervention or thrombolytic therapy is essential in restoring blood flow and salvaging the jeopardized myocardium. The role of adjunctive medical treatment, including antiplatelet agents, beta-blockers, and statins, will also be discussed in post-STEMI management. en_US
dc.language.iso eng
dc.publisher Wolters Kluwer Health
dc.relation.ispartofseries Medicine
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject American College of Cardiology en_US
dc.subject American Heart Association en_US
dc.subject Creatine Kinase-MB en_US
dc.subject European Society of Cardiology en_US
dc.subject Global Registry of Acute Coronary Events en_US
dc.subject Left Ventricular Ejection Fraction en_US
dc.subject ST-segment Elevation Myocardial Infarction en_US
dc.subject.mesh Forma MB de la Creatina-Quinasa
dc.subject.mesh Cardiología
dc.subject.mesh Función Ventricular Izquierda
dc.subject.mesh Infarto del Miocardio sin Elevación del ST
dc.title Comprehensive review of ST-segment elevation myocardial infarction: Understanding pathophysiology, diagnostic strategies, and current treatment approaches en_US
dc.type info:eu-repo/semantics/review
dc.identifier.doi https://doi.org/10.1097/MD.0000000000035687
dc.relation.issn 1536-5964


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