DSpace Repository

Emergence of Rhino-Orbito-Cerebral Mucormycosis in Peru: Impact of the COVID-19 Pandemic

Show simple item record

dc.contributor.author Cumpa-Quiroz, Robert
dc.contributor.author Elguera-Falcón, Federico
dc.contributor.author Guevara Lazo, David Rafael
dc.date.accessioned 2023-12-05T17:47:59Z
dc.date.available 2023-12-05T17:47:59Z
dc.date.issued 2023
dc.identifier.uri https://hdl.handle.net/20.500.12866/14628
dc.description.abstract Introduction: Mucormycosis is an invasive fungal infection caused by Mucorales that has been increasingly recognized over the years, particularly during the COVID-19 pandemic. Nevertheless, in Peru, there has been limited research on this disease. This study seeks to provide insights into the demographics, clinical presentations, treatment, and outcomes of patients with mucormycosis, before and during the COVID-19 pandemic. Materials and methods: We conducted a retrospective case series by reviewing the medical records of Peruvian patients hospitalized at a referral medical center between 2017 and 2021. The selection criteria included patients aged 18 years or older with clinical features of rhino-orbito-cerebral mucormycosis supported by radiological imaging. We extracted data related to risk factors for mucormycosis infection, clinical presentation, management, and hospitalization. Data analysis was performed using Stata software (StataCorp LLC, College Station, Texas, USA) to compare patient groups before and during the COVID-19 pandemic. Results: Nineteen cases met our selection criteria: 11 men and eight women with an average age of 57.6 +/- 10.6 years. All 19 patients had type 2 diabetes mellitus as comorbidity, with 13 cases exhibiting uncontrolled diabetes. Six patients presented before the COVID-19 pandemic, while 13 during its course. Within the group of patients diagnosed during the pandemic, nine were diagnosed with SARS-CoV-2 infection. Regarding the site of mucormycosis infection, the paranasal sinuses were predominantly involved. Survival analysis indicated that patients who developed mucormycosis during the COVID-19 pandemic, those with uncontrolled diabetes, or those who did not undergo surgery had lower probabilities of survival. Conclusion: Mucormycosis is a rare infection associated with high mortality and morbidity with increased frequency during the COVID-19 pandemic. Early diagnosis, timely administration of antifungal treatment, surgery, and effective management of comorbidities can have life-saving implications. Unfortunately, despite the availability of various diagnostic tests and less toxic antifungal options such as liposomal amphotericin-B, such resources are not accessible in Peru's national hospitals. en_US
dc.language.iso eng
dc.publisher Springer
dc.relation.ispartofseries Cureus Journal of Medical Science
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Emergence en_US
dc.subject Rhino-Orbito-Cerebral en_US
dc.subject Mucormycosis en_US
dc.subject Peru en_US
dc.subject COVID-19 en_US
dc.subject Pandemic en_US
dc.subject.mesh Urgencias Médicas
dc.subject.mesh Mucormicosis
dc.subject.mesh Perú
dc.subject.mesh COVID-19
dc.subject.mesh Pandemia
dc.title Emergence of Rhino-Orbito-Cerebral Mucormycosis in Peru: Impact of the COVID-19 Pandemic en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.7759/cureus.45240
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#1.06.05
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.09
dc.relation.issn 2168-8184


Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

info:eu-repo/semantics/restrictedAccess Except where otherwise noted, this item's license is described as info:eu-repo/semantics/restrictedAccess

Search DSpace


Browse

My Account

Statistics