Universidad Peruana Cayetano Heredia

Frequency of functional esophageal disorders in patients with refractory reflux symptoms in Lima, Peru

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dc.contributor.author Piza Palacios, Luis Antonio
dc.contributor.author Cárdenas Oña, Mercedes
dc.contributor.author Vasquez Ojeda, Ximena Paola
dc.contributor.author Alurralde, Carmen
dc.contributor.author Rosas, Edith
dc.contributor.author Samalvides Cuba, Frine
dc.contributor.author Espinoza Ríos, Jorge Luis
dc.coverage.spatial Lima, Perú
dc.date.accessioned 2023-12-05T17:48:00Z
dc.date.available 2023-12-05T17:48:00Z
dc.date.issued 2023
dc.identifier.uri https://hdl.handle.net/20.500.12866/14632
dc.description.abstract Gastroesophageal reflux disease (GERD) is a clinical condition in which gastric reflux causes symptoms or damage to the esophageal mucosa. It is managed with proton pump inhibitors, however, up to 45% of patients with suspected GERD are refractory to treatment. It is necessary to establish a true GERD diagnosis by means of a digestive endoscopy, which does not show lesions in approximately 70% of patients. In this scenario, it is necessary to perform an esophageal pH-impedance measurement, a procedure that allows to determine whether exposure to gastric acid is pathological. Of this group, patients with pathological acid exposure are diagnosed as true non-erosive reflux disease (NERD). If, in addition to not presenting esophageal lesions, they have a physiological exposure to gastric acid, they suffer from esophageal hypersensitivity or functional heartburn, which are functional disorders. These require a different approach from that of GERD or NERD, as the symptoms are not due to pathological exposure to gastric acid. The aim was to calculate the frequency of esophageal hypersensitivity and functional heartburn in patients with suspected NERD. This was a cross-sectional study. Data was collected by reviewing pH-impedance and manometry reports, 166 patients were selected. The frequency for functional disorders was 86.15%, being 46.9% for functional heartburn and 39.2% for esophageal hypersensitivity. The frequency of functional disorders was higher than that reported in previous studies. In conclusion, age, psychological conditions, dietary, cultural, ethnic or lifestyle factors inherent to our environment might play important roles in the development of functional disorders. en_US
dc.language.iso eng
dc.publisher Sociedad de Gastroenterología del Perú
dc.relation.ispartofseries Revista de Gastroenterologia del Peru
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Gastroesophageal Reflux en_US
dc.subject Esophageal pH Monitoring en_US
dc.subject Functional gastrointestinal disorders en_US
dc.subject Heartburn en_US
dc.subject.mesh Reflujo Gastroesofágico
dc.subject.mesh Monitorización del pH Esofágico
dc.subject.mesh Enfermedades Gastrointestinales
dc.subject.mesh Pirosis
dc.title Frequency of functional esophageal disorders in patients with refractory reflux symptoms in Lima, Peru en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.47892/rgp.2023.433.1498
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.19
dc.relation.issn 1609-722X


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