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Mapping SARS-CoV-2 antigenic relationships and serological responses

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dc.contributor.author Wilks, Samuel H.
dc.contributor.author Mühlemann, Barbara
dc.contributor.author Shen, Xiaoying
dc.contributor.author Türeli, Sina
dc.contributor.author LeGresley, Eric B.
dc.contributor.author Netzl, Antonia
dc.contributor.author Caniza, Miguela A.
dc.contributor.author Chacaltana-Huarcaya, Jesus N.
dc.contributor.author Corman, Victor M.
dc.contributor.author Daniell, Xiaoju
dc.contributor.author Datto, Michael B.
dc.contributor.author Dawood, Fatimah S.
dc.contributor.author Denny, Thomas N.
dc.contributor.author Drosten, Christian
dc.contributor.author Fouchier, Ron A. M.
dc.contributor.author Garcia Funegra, Patricia Jannet
dc.contributor.author Halfmann, Peter J.
dc.contributor.author Jassem, Agatha
dc.contributor.author Jeworowski, Lara M.
dc.contributor.author Jones, Terry C.
dc.contributor.author Kawaoka, Yoshihiro
dc.contributor.author Krammer, Florian
dc.contributor.author McDanal, Charlene
dc.contributor.author Pajon, Rolando
dc.contributor.author Simon, Viviana
dc.contributor.author Stockwell, Melissa S.
dc.contributor.author Tang, Haili
dc.contributor.author van Bakel, Harm
dc.contributor.author Veguilla, Vic
dc.contributor.author Webby, Richard
dc.contributor.author Montefiori, David C.
dc.contributor.author Smith, Derek J.
dc.date.accessioned 2023-12-05T17:48:01Z
dc.date.available 2023-12-05T17:48:01Z
dc.date.issued 2023
dc.identifier.uri https://hdl.handle.net/20.500.12866/14643
dc.description.abstract During the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, multiple variants escaping preexisting immunity emerged, causing reinfections of previously exposed individuals. Here, we used antigenic cartography to analyze patterns of cross-reactivity among 21 variants and 15 groups of human sera obtained after primary infection with 10 different variants or after messenger RNA (mRNA)–1273 or mRNA-1273.351 vaccination. We found antigenic differences among pre-Omicron variants caused by substitutions at spike-protein positions 417, 452, 484, and 501. Quantifying changes in response breadth over time and with additional vaccine doses, our results show the largest increase between 4 weeks and >3 months after a second dose. We found changes in immunodominance of different spike regions, depending on the variant an individual was first exposed to, with implications for variant risk assessment and vaccine-strain selection. en_US
dc.language.iso eng
dc.publisher American Association for the Advancement of Science
dc.relation.ispartofseries Science
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject SARS-CoV-2 en_US
dc.subject Antigenic en_US
dc.subject Serological en_US
dc.subject.mesh SARS-CoV-2
dc.subject.mesh Modulación Antigénica
dc.subject.mesh Prueba Serológica para COVID-19
dc.title Mapping SARS-CoV-2 antigenic relationships and serological responses en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1126/science.adj0070
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.01.01
dc.relation.issn 1095-9203


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