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Mechanisms underlying the health benefits of intermittent hypoxia conditioning

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dc.contributor.author Burtscher, Johannes
dc.contributor.author Citherlet, Tom
dc.contributor.author Camacho-Cardenosa, Alba
dc.contributor.author Camacho-Cardenosa, Marta
dc.contributor.author Raberin, Antoine
dc.contributor.author Krumm, Bastien
dc.contributor.author Hohenauer, Erich
dc.contributor.author Egg, Margit
dc.contributor.author Lichtblau, Mona
dc.contributor.author Müller, Julian
dc.contributor.author Rybnikova, Elena A.
dc.contributor.author Gatterer, Hannes
dc.contributor.author Debevec, Tadej
dc.contributor.author Baillieul, Sebastien
dc.contributor.author Manferdelli, Giorgio
dc.contributor.author Behrendt, Tom
dc.contributor.author Schega, Lutz
dc.contributor.author Ehrenreich, Hannelore
dc.contributor.author Millet, Grégoire P.
dc.contributor.author Gassmann Mendez, Max
dc.contributor.author Schwarzer, Christoph
dc.contributor.author Glazachev, Oleg
dc.contributor.author Girard, Olivier
dc.contributor.author Lalande, Sophie
dc.contributor.author Hamlin, Michael
dc.contributor.author Samaja, Michele
dc.contributor.author Hüfner, Katharina
dc.contributor.author Burtscher, Martin
dc.contributor.author Panza, Gino
dc.contributor.author Mallet, Robert T.
dc.date.accessioned 2023-12-05T17:48:02Z
dc.date.available 2023-12-05T17:48:02Z
dc.date.issued 2023
dc.identifier.uri https://hdl.handle.net/20.500.12866/14645
dc.description.abstract Intermittent hypoxia (IH) is commonly associated with pathological conditions, particularly obstructive sleep apnoea. However, IH is also increasingly used to enhance health and performance and is emerging as a potent non-pharmacological intervention against numerous diseases. Whether IH is detrimental or beneficial for health is largely determined by the intensity, duration, number and frequency of the hypoxic exposures and by the specific responses they engender. Adaptive responses to hypoxia protect from future hypoxic or ischaemic insults, improve cellular resilience and functions, and boost mental and physical performance. The cellular and systemic mechanisms producing these benefits are highly complex, and the failure of different components can shift long-term adaptation to maladaptation and the development of pathologies. Rather than discussing in detail the well-characterized individual responses and adaptations to IH, we here aim to summarize and integrate hypoxia-activated mechanisms into a holistic picture of the body's adaptive responses to hypoxia and specifically IH, and demonstrate how these mechanisms might be mobilized for their health benefits while minimizing the risks of hypoxia exposure. en_US
dc.language.iso eng
dc.publisher Wiley
dc.relation.ispartofseries Journal of Physiology
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Cardiovascular diseases en_US
dc.subject Cellular stress responses en_US
dc.subject Intermittent hypoxia conditioning en_US
dc.subject Mitochondria en_US
dc.subject Neurological disorders en_US
dc.subject Oxygen sensing en_US
dc.subject.mesh Enfermedades Cardiovasculares
dc.subject.mesh Hipoxia
dc.subject.mesh Mitocondrias
dc.subject.mesh Enfermedades del Sistema Nervioso
dc.subject.mesh Nivel de Oxígeno
dc.title Mechanisms underlying the health benefits of intermittent hypoxia conditioning en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1113/JP285230
dc.relation.issn 1469-7793


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