Universidad Peruana Cayetano Heredia

Oral lactoferrin administration does not impact the diversity or composition of the infant gut microbiota in a Peruvian cohort.

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dc.contributor.author Gonzalez Villaseca, Luis Antonio
dc.contributor.author Paredes Sosa, José Luis
dc.contributor.author Mosquito Guillen, Susan Grace
dc.contributor.author Filio Azañedo, Yesenia
dc.contributor.author Romero, Pedro E.
dc.contributor.author Ochoa Woodell, Theresa Jean
dc.contributor.author Tsukayama Cisneros, Pablo
dc.date.accessioned 2023-12-05T17:48:03Z
dc.date.available 2023-12-05T17:48:03Z
dc.date.issued 2023
dc.identifier.uri https://hdl.handle.net/20.500.12866/14659
dc.description.abstract Lactoferrin is a protein from breast milk involved in early-life microbiome assembly. It is believed to promote the growth of lactic acid-producing bacteria and inhibit pathogens by limiting iron availability and enabling an acidic environment in the gut. Previous reports suggest that oral administration of lactoferrin in neonates promotes the increase of gut microbiota diversity and the enrichment of beneficial microbes. However, its effect on infant gut microbiota over time has yet to be thoroughly studied to fully understand its potential as a prebiotic. Using 16s rRNA gene amplicon sequencing, we analyzed the gut microbiota composition of 60 toddlers at 12-18 months of age from Lima, Peru, who received daily oral administration of lactoferrin or placebo for 6 months since enrollment. Samples were analyzed at 0, 2, and 4 months after beginning treatment. Our results show that lactoferrin treatment does not increase gut microbiota diversity over time nor affect its bacterial composition compared to the placebo group.IMPORTANCEPrevious studies have suggested that oral lactoferrin enhances diversity in the gut microbiota in infants while inhibiting the growth of opportunistic pathogens. However, the effect of lactoferrin on infant gut microbiota over time has yet to be thoroughly studied. Our study suggests that lactoferrin oral treatment in infants aged 12-18 months does not affect gut microbiome diversity and composition over time. To our knowledge, this is the first study to report the effect of lactoferrin on infant gut microbiome composition over time and helps elucidate its impact on infant health and its therapeutic potential. en_US
dc.language.iso eng
dc.publisher American Society for Microbiology
dc.relation.ispartofseries Microbiology Spectrum
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Lactoferrin en_US
dc.subject Early life microbiome en_US
dc.subject 16S rRNA sequencing en_US
dc.subject Peru en_US
dc.subject Gut microbiota en_US
dc.subject.mesh Lactoferrina
dc.subject.mesh Microbiota
dc.subject.mesh Análisis de Secuencia de ARN
dc.subject.mesh Perú
dc.subject.mesh Microbioma Gastrointestinal
dc.title Oral lactoferrin administration does not impact the diversity or composition of the infant gut microbiota in a Peruvian cohort. en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1128/spectrum.00096-23
dc.relation.issn 2165-0497


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