Schwalb and Houben Respond to "The Winding Road to ARTI"

Houben, RMGJ; Schwalb Calderon, Alvaro

dc.contributor.author	Schwalb Calderon, Alvaro
dc.contributor.author	Houben, RMGJ
dc.date.accessioned	2023-12-05T17:48:04Z
dc.date.available	2023-12-05T17:48:04Z
dc.date.issued	2023
dc.identifier.uri	https://hdl.handle.net/20.500.12866/14669
dc.description.abstract	We appreciate the commentary by Prof. Horsburgh on our article, particularly as it stimulates further discussion on where the true annual risk of infection (ARI) of Mycobacterium tuberculosis lies. Even though the phenomenon of immunoreactivity reversion is neither new nor rare, its implications for the estimation of the ARI have been largely dismissed. Given how the ARI is calculated, the observed changes in immunoreactivity lead to concrete discrepancies in the metric when accounting for reversion. Our work explored how ARI estimation is affected when accounting for varying reversion probabilities ranging from 0% per year to 50% per year, covering a wide range of scenarios. Note that in our paper and this response, we consider reversion the observed process of waning immunoreactivity, rather than an underlying mechanism such as self-cure...	en_US
dc.language.iso	eng
dc.publisher	Oxford University Press
dc.relation.ispartofseries	American Journal of Epidemiology
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.subject	Respond	en_US
dc.subject	The Winding Road to ARTI	en_US
dc.subject	Annual Risk of Infection	en_US
dc.subject	Tuberculosis	en_US
dc.subject.mesh	Tuberculosis
dc.subject.mesh	Infecciones
dc.title	Schwalb and Houben Respond to "The Winding Road to ARTI"	en_US
dc.type	info:eu-repo/semantics/article
dc.identifier.doi	https://doi.org/10.1093/aje/kwad163
dc.subject.ocde	https://purl.org/pe-repo/ocde/ford#3.03.09
dc.relation.issn	1476-6256