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Sex differences in the etiology and burden of heart failure across country income level: analysis of 204 countries and territories 1990-2019.

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dc.contributor.author Wei, Sunny
dc.contributor.author Miranda, J. Jaime
dc.contributor.author Mamas, Mamas A.
dc.contributor.author Zühlke, Liesl J.
dc.contributor.author Kontopantelis, Evan
dc.contributor.author Thabane, Lehana
dc.contributor.author Van Spall, Harriette G. C.
dc.date.accessioned 2023-12-05T17:48:04Z
dc.date.available 2023-12-05T17:48:04Z
dc.date.issued 2023
dc.identifier.uri https://hdl.handle.net/20.500.12866/14670
dc.description.abstract BACKGROUND: Heart failure (HF) is a global epidemic. OBJECTIVE: To assess global sex differences in HF epidemiology across country income levels. METHODS AND RESULTS: Using Global Burden of Disease (GBD) data from 204 countries and territories 1990-2019, we assessed sex differences in HF prevalence, etiology, morbidity, and temporal trends across country sociodemographic index or gross national income. We derived age-standardized rates. Of 56.2 million (95% uncertainty interval [UI] 46.4-67.8 million) people with HF in 2019, 50.3% were females and 69.2% lived in low- and middle-income countries; age-standardized prevalence was greater in males and in high-income countries. Ischaemic and hypertensive heart disease were top causes of HF in males and females, respectively. There were 5.1 million (95% UI 3.3-7.3 million) years lived with disability, distributed equally between sexes. Between 1990 and 2019, there was an increase in HF cases, but a decrease in age-standardized rates per 100 000 in males (9.1%, from 864.2 to 785.7) and females (5.8%, from 686.0 to 646.1). High-income regions experienced a 16.0% decrease in age-standardized rates (from 877.5 to 736.8), while low-income regions experienced a 3.9% increase (from 612.1 to 636.0), largely consistent across sexes. There was a temporal increase in age-standardized HF from hypertensive, rheumatic, and calcific aortic valvular heart disease, and a decrease from ischaemic heart disease, with regional and sex differences. CONCLUSION: Age-standardized HF rates have decreased over time, with larger decreases in males than females; and with large decreases in high-income and small increases in low-income regions. Sex and regional differences offer targets for intervention. en_US
dc.language.iso eng
dc.publisher Oxford University Press
dc.relation.ispartofseries European Heart Journal. Quality of Care and Clinical Outcomes
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Epidemiology en_US
dc.subject Male en_US
dc.subject Female en_US
dc.subject Global Burden of Disease en_US
dc.subject Morbidity en_US
dc.subject.mesh Epidemiología
dc.subject.mesh Masculino
dc.subject.mesh Femenino
dc.subject.mesh Carga Global de Enfermedades
dc.subject.mesh Morbilidad
dc.title Sex differences in the etiology and burden of heart failure across country income level: analysis of 204 countries and territories 1990-2019. en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1093/ehjqcco/qcac088
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.04
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.09
dc.relation.issn 2058-1742


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