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Visceral larva Migrans in a Young Italian Patient: A Diagnostic Dilemma

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dc.contributor.author Francalanci, E.
dc.contributor.author Manciulli, T.
dc.contributor.author Bandini, G.
dc.contributor.author Blanc, P.
dc.contributor.author Bonelli, S.I.
dc.contributor.author Brunetti, E.
dc.contributor.author Gotuzzo Herencia, José Eduardo
dc.contributor.author Cretu, C.M.
dc.contributor.author Gobbi, F.
dc.contributor.author Bartoloni, A.
dc.contributor.author Zammarchi, L.
dc.date.accessioned 2023-12-05T17:48:05Z
dc.date.available 2023-12-05T17:48:05Z
dc.date.issued 2023
dc.identifier.uri https://hdl.handle.net/20.500.12866/14682
dc.description.abstract Background: The association of fever, focal hepatic lesions and peripheral hyper-eosinophilia (FHLH) can be observed in both infectious and non-infectious conditions. Fascioliasis, capillariasis, toxocariasis, all causes of visceral larva migrans (VLM), represent most of the former, whilst lymphomas, eosinophilic leukemias and mastocytosis belong in the non-infectious conditions. Methods: We prospectively followed a young patient presenting with FHLH in the Tuscany region of Italy. Results: The patient was subject to serological and parasitological examination in an attempt to clarify the origin of the lesions. Serologies for both Fasciola hepatica and Toxocara spp. were positive, with the latter presenting a higher index. We opted for treatment with a prolonged course of albendazole due to the serological results and being toxocariasis more frequent in our setting. The patient was then subject to radiological follow-up. The patient responded to treatment with albendazole as shown by a decrease in eosinophils, seronegativization for Toxocara spp., clinical and radiological improvement. Toxocariasis was hence considered the most likely diagnosis. Conclusions: Parasitic infections cannot be disregarded in the presence of FHLH. Differential diagnosis between these parasitic infections can be challenging due to the presence of similar clinical presentations and serological cross-reactions, and follow-up of the patient is needed to ensure optimal treatment outcomes. en_US
dc.language.iso eng
dc.publisher Springer
dc.relation.ispartofseries Acta Parasitologica
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Visceral larva migrans en_US
dc.subject Toxocariasis en_US
dc.subject Fascioliasis en_US
dc.subject Focal liver lesion en_US
dc.subject Diagnosis en_US
dc.subject Serology en_US
dc.subject.mesh Larva Migrans Visceral
dc.subject.mesh Toxocariasis
dc.subject.mesh Fascioliasis
dc.subject.mesh Hígado
dc.subject.mesh Diagnóstico
dc.subject.mesh Serología
dc.title Visceral larva Migrans in a Young Italian Patient: A Diagnostic Dilemma en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1007/s11686-023-00723-9
dc.relation.issn 1896-1851


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