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Pneumonia Mortality Trends in Children under 5 Years of Age in the Context of Pneumococcal Conjugate Vaccination in Peru, 2003-2017.

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dc.contributor.author Sanchez, Carlos A.
dc.contributor.author Lozada-Urbano, Michelle
dc.contributor.author Best Bandenay, Pablo Yvan
dc.coverage.spatial Perú
dc.date.accessioned 2023-12-07T22:33:24Z
dc.date.available 2023-12-07T22:33:24Z
dc.date.issued 2023
dc.identifier.uri https://hdl.handle.net/20.500.12866/14717
dc.description.abstract Worldwide, conjugated pneumococcal vaccines (PCVs) have proven effective against invasive pneumococcal disease, but non-invasive pneumonia is a major cause of mortality in young children and serotypes vary geographically, affecting effectiveness. We analyze nationwide death certificate data between 2003-2017 to assess the impact of PCVs on pneumonia mortality among young children from Peru. We report descriptive statistics and perform timeseries analysis on annual mortality rates (AMRs) and monthly frequencies of pneumonia deaths. Children under 5 years of age accounted for 6.2% (n = 10,408) of all pneumonia deaths (N = 166,844), and 32.3% (n = 3363) were children between 1-4 years of age, of which 95.1% did not report pneumonia etiology. Comparing periods before and after PCV introduction in 2009, mean AMRs dropped 13.5% and 26.0% for children between 1-4 years of age (toddlers/preschoolers), and children under 1 year of age (infants), respectively. A moderate correlation (Spearman's r = 0.546, p < 0.01) in the monthly frequency of pneumonia deaths was estimated between both age groups. Quadratic regression suggests a change in direction around 2005 (highest pneumonia mortality) for both age groups, but percentage change analysis identified an inflection point in 2013 for infants only, not for toddlers/preschoolers, suggesting that the impact of PCVs might be different for each age group. en_US
dc.language.iso eng
dc.publisher MDPI
dc.relation.ispartofseries Vaccines
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Pneumonia en_US
dc.subject Streptococcus pneumoniae en_US
dc.subject pneumococcal conjugate vaccine en_US
dc.subject Herd immunity en_US
dc.subject Peru en_US
dc.subject.mesh Neumonía
dc.subject.mesh Streptococcus pneumoniae
dc.subject.mesh Vacuna Neumocócica Conjugada Heptavalente
dc.subject.mesh Inmunidad Colectiva
dc.subject.mesh Perú
dc.title Pneumonia Mortality Trends in Children under 5 Years of Age in the Context of Pneumococcal Conjugate Vaccination in Peru, 2003-2017. en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.3390/vaccines11111715
dc.relation.issn 2076-393X


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