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Novel antibodies directed against the human erythropoietin receptor: Creating a basis for clinical implementation

Maxwell, P.; Melendez-Rodríguez, F.; Matchett, K.B.; Aragones, J.; Ben-Califa, N.; Jaekel, H.; Hengst, L.; Lindner, H.; Bernardini, A.; Brockmeier, U.; Fandrey, J.; Grunert, F.; Oster, H.S.; Mittelman, M.; El-Tanani, M.; Thiersch, M.; Schneider Gasser, E.M.; Gassmann, M.; Dangoor, D.; Cuthbert, R.J.; Irvine, A.; Jordan, A.; Lappin, T.; Thompson, J.; Neumann, D. (Wiley, 2014)

Recombinant human erythropoietin (rHuEPO) is an effective treatment for anaemia but concerns that it causes disease progression in cancer patients by activation of EPO receptors (EPOR) in tumour tissue have been controversial ...

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