Universidad Peruana Cayetano Heredia

Antibody banding patterns of the enzyme-linked immunoelectrotransfer blot and brain imaging findings in patients with Neurocysticercosis

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dc.contributor.author Arroyo Hurtado, Gianfranco
dc.contributor.author Rodriguez, Silvia
dc.contributor.author Lescano Guevara, Andres Guillermo
dc.contributor.author Alroy, Karen A.
dc.contributor.author Bustos Palomino, Javier Arturo
dc.contributor.author Santivañez, Saul
dc.contributor.author Gonzales, Isidro
dc.contributor.author Saavedra Pastor, Herbert
dc.contributor.author Pretell, E. Javier
dc.contributor.author Gonzalez Zariquiey, Armando Emiliano
dc.contributor.author Gilman, Robert Hugh
dc.contributor.author Tsang, Victor C. W.
dc.contributor.author García Lescano, Héctor Hugo
dc.contributor.author Cysticercosis Working Group in Peru
dc.date.accessioned 2018-11-30T02:09:29Z
dc.date.available 2018-11-30T02:09:29Z
dc.date.issued 2018
dc.identifier.uri https://hdl.handle.net/20.500.12866/4000
dc.description.abstract Background: The enzyme-linked immunoelectrotransfer blot (EITB) assay is the reference serological test for neurocysticercosis (NCC). A positive result on EITB does not always correlate with the presence of active infections in the central nervous system (CNS), and patients with a single viable brain cyst may be EITB negative. Nonetheless, EITB antibody banding patterns appears to be related with the expression of 3 protein families of Taenia solium, and in turn with the characteristics of NCC in the CNS (type, stage, and burden of viable cysts). Methods: We evaluated EITB antibody banding patterns and brain imaging findings of 548 NCC cases. Similar banding patterns were grouped into homogeneous classes using latent class analysis. The association between classes and brain imaging findings was assessed. Results: Four classes were identified. Class 1 (patients negative or only positive to the GP50 band, related to the protein family of the same name) was associated with nonviable or single viable parenchymal cysticerci; class 2 (patients positive to bands GP42-39 and GP24, related to the T24-42 protein family, with or without anti-GP50 antibodies) was associated with intraparenchymal viable and nonviable infections; classes 3 and 4 (positive to GP50, GP42-39, and GP24 but also responding to low molecular weight bands GP21, GP18, GP14, and GP13, related to the 8 kDa protein family) were associated with extraparenchymal and intraparenchymal multiple viable cysticerci. Conclusions: EITB antibody banding patterns correlate with brain imaging findings and complement imaging information for the diagnosis of NCC and for staging NCC patients. en_US
dc.description.sponsorship Este trabajo fue parcialmente financiado por el Centro Internacional Fogarty/NIH [becas de capacitación números D43TW001140 y D43TW007393] y por el Consejo Nacional de Ciencia, Tecnología e Innovación del Perú (CONCYTEC). es_PE
dc.language.iso eng
dc.publisher Oxford University Press
dc.relation.ispartofseries Clinical Infectious Diseases
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Peru en_US
dc.subject Taenia solium en_US
dc.subject neurocysticercosis en_US
dc.subject epilepsy en_US
dc.subject EITB en_US
dc.title Antibody banding patterns of the enzyme-linked immunoelectrotransfer blot and brain imaging findings in patients with Neurocysticercosis en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1093/cid/cix774
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.08
dc.relation.issn 1537-6591


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