Universidad Peruana Cayetano Heredia

Aqueous extract of yellow maca (Lepidium meyenii) improves sperm count in experimental animals but response depends on hypocotyl size, pH and routes of administration

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dc.contributor.author Sanchez-Salazar, L.
dc.contributor.author Gonzales Rengifo, Gustavo Francisco
dc.date.accessioned 2018-11-30T02:09:29Z
dc.date.available 2018-11-30T02:09:29Z
dc.date.issued 2018
dc.identifier.uri https://hdl.handle.net/20.500.12866/4002
dc.description.abstract Lepidium meyenii, a Peruvian plant growing over 4000 m.a.s.l., has effects on nutrition and fertility. The purpose of this study was to evaluate the sperm count in 105 male mice receiving boiled aqueous extract of yellow maca hypocotyls from different sizes, under different pH conditions and using two different routes of administration. Five mice per group were treated daily for 3 days with vehicle (oral and intraperitoneal) or maca aqueous extracts (5 mg/0.5 ml/day) belonging to the first, second, third and fourth categories, according to their hypocotyl size. On day four, sperm count was evaluated at testis, epididymis and vas deferens. Sperm count was higher in mice receiving maca from the larger sizes (first and second categories). Reduction in maca extract pH increased sperm count, whereas an increase in the pH resulted in a reduction in sperm count. The effect of pH reduction is observed only in maca from the first and second categories. Aqueous extract of maca was effective only after oral administration. In conclusion, the larger size of hypocotyls presented the best biological effect, and the low pH in the extract and the transformation after gastrointestinal passage are both important for its biological action. en_US
dc.language.iso eng
dc.publisher Wiley
dc.relation.ispartofseries Andrologia
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Male en_US
dc.subject Animals en_US
dc.subject Plant Extracts en_US
dc.subject Central Andes en_US
dc.subject Epididymis en_US
dc.subject fertility en_US
dc.subject Huallanca en_US
dc.subject Lepidium en_US
dc.subject maca phenotypes en_US
dc.subject Mice en_US
dc.subject nutraceutics en_US
dc.subject Sperm Count en_US
dc.subject Spermatogenesis en_US
dc.subject Spermatozoa en_US
dc.subject Testis en_US
dc.subject Vas Deferens en_US
dc.title Aqueous extract of yellow maca (Lepidium meyenii) improves sperm count in experimental animals but response depends on hypocotyl size, pH and routes of administration en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1111/and.12929
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.01
dc.relation.issn 1439-0272


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