Aqueous extract of yellow maca (Lepidium meyenii) improves sperm count in experimental animals but response depends on hypocotyl size, pH and routes of administration

Gonzales Rengifo, Gustavo Francisco; Sanchez-Salazar, L.

dc.contributor.author	Sanchez-Salazar, L.
dc.contributor.author	Gonzales Rengifo, Gustavo Francisco
dc.date.accessioned	2018-11-30T02:09:29Z
dc.date.available	2018-11-30T02:09:29Z
dc.date.issued	2018
dc.identifier.uri	https://hdl.handle.net/20.500.12866/4002
dc.description.abstract	Lepidium meyenii, a Peruvian plant growing over 4000 m.a.s.l., has effects on nutrition and fertility. The purpose of this study was to evaluate the sperm count in 105 male mice receiving boiled aqueous extract of yellow maca hypocotyls from different sizes, under different pH conditions and using two different routes of administration. Five mice per group were treated daily for 3 days with vehicle (oral and intraperitoneal) or maca aqueous extracts (5 mg/0.5 ml/day) belonging to the first, second, third and fourth categories, according to their hypocotyl size. On day four, sperm count was evaluated at testis, epididymis and vas deferens. Sperm count was higher in mice receiving maca from the larger sizes (first and second categories). Reduction in maca extract pH increased sperm count, whereas an increase in the pH resulted in a reduction in sperm count. The effect of pH reduction is observed only in maca from the first and second categories. Aqueous extract of maca was effective only after oral administration. In conclusion, the larger size of hypocotyls presented the best biological effect, and the low pH in the extract and the transformation after gastrointestinal passage are both important for its biological action.	en_US
dc.description.sponsorship	Este trabajo fue financiado en el marco del Círculo de Investigación en Plantas con Efectos en la Salud por CONCYTEC [número de contrato 010 - 2014-FONDECYT].	es_PE
dc.language.iso	eng
dc.publisher	Wiley
dc.relation.ispartofseries	Andrologia
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.subject	Male	en_US
dc.subject	Animals	en_US
dc.subject	Plant Extracts	en_US
dc.subject	Central Andes	en_US
dc.subject	Epididymis	en_US
dc.subject	fertility	en_US
dc.subject	Huallanca	en_US
dc.subject	Lepidium	en_US
dc.subject	maca phenotypes	en_US
dc.subject	Mice	en_US
dc.subject	nutraceutics	en_US
dc.subject	Sperm Count	en_US
dc.subject	Spermatogenesis	en_US
dc.subject	Spermatozoa	en_US
dc.subject	Testis	en_US
dc.subject	Vas Deferens	en_US
dc.title	Aqueous extract of yellow maca (Lepidium meyenii) improves sperm count in experimental animals but response depends on hypocotyl size, pH and routes of administration	en_US
dc.type	info:eu-repo/semantics/article
dc.identifier.doi	https://doi.org/10.1111/and.12929
dc.subject.ocde	https://purl.org/pe-repo/ocde/ford#3.02.01
dc.type.version	info:eu-repo/semantics/publishedVersion
dc.relation.issn	1439-0272