Association between household air pollution exposure and Chronic Obstructive Pulmonary Disease outcomes in 13 low- and middle-income country settings

Siddharthan, Trishul; Alam, Dewan; Wise, Robert A.; Miranda, J. Jaime; Kirenga, Bruce; Chowdhury, Muhammad; Goodman, Dina; van Gemert, Frederick; Grigsby, Matthew R.; Checkley, William; Irazola, Vilma; Gutierrez, Laura; Rubinstein, Adolfo; Bernabé Ortiz, Antonio; Jones, Rupert

dc.contributor.author	Siddharthan, Trishul
dc.contributor.author	Grigsby, Matthew R.
dc.contributor.author	Goodman, Dina
dc.contributor.author	Chowdhury, Muhammad
dc.contributor.author	Rubinstein, Adolfo
dc.contributor.author	Irazola, Vilma
dc.contributor.author	Gutierrez, Laura
dc.contributor.author	Miranda, J. Jaime
dc.contributor.author	Bernabé Ortiz, Antonio
dc.contributor.author	Alam, Dewan
dc.contributor.author	Kirenga, Bruce
dc.contributor.author	Jones, Rupert
dc.contributor.author	van Gemert, Frederick
dc.contributor.author	Wise, Robert A.
dc.contributor.author	Checkley, William
dc.date.accessioned	2018-11-30T02:09:30Z
dc.date.available	2018-11-30T02:09:30Z
dc.date.issued	2018
dc.identifier.uri	https://hdl.handle.net/20.500.12866/4005
dc.description.abstract	RATIONALE: Forty percent of households worldwide burn biomass fuels for energy, which may be the most important contributor to household air pollution. OBJECTIVES: To examine the association between household air pollution exposure and chronic obstructive pulmonary disease (COPD) outcomes in 13 resource-poor settings. METHODS: We analyzed data from 12,396 adult participants living in 13 resource-poor, population-based settings. Household air pollution exposure was defined as using biomass materials as the primary fuel source in the home. We used multivariable regressions to assess the relationship between household air pollution exposure and COPD outcomes, evaluated for interactions, and conducted sensitivity analyses to test the robustness of our findings. MEASUREMENTS AND MAIN RESULTS: Average age was 54.9 years (44.2-59.6 yr across settings), 48.5% were women (38.3-54.5%), prevalence of household air pollution exposure was 38% (0.5-99.6%), and 8.8% (1.7-15.5%) had COPD. Participants with household air pollution exposure were 41% more likely to have COPD (adjusted odds ratio, 1.41; 95% confidence interval, 1.18-1.68) than those without the exposure, and 13.5% (6.4-20.6%) of COPD prevalence may be caused by household air pollution exposure, compared with 12.4% caused by cigarette smoking. The association between household air pollution exposure and COPD was stronger in women (1.70; 1.24-2.32) than in men (1.21; 0.92-1.58). CONCLUSIONS: Household air pollution exposure was associated with a higher prevalence of COPD, particularly among women, and it is likely a leading population-attributable risk factor for COPD in resource-poor settings.	en_US
dc.language.iso	eng
dc.publisher	American Thoracic Society
dc.relation.ispartofseries	American Journal of Respiratory and Critical Care Medicine
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.subject	COPD	en_US
dc.subject	air pollution	en_US
dc.subject	biomass	en_US
dc.subject	indoor/adverse effects	en_US
dc.title	Association between household air pollution exposure and Chronic Obstructive Pulmonary Disease outcomes in 13 low- and middle-income country settings	en_US
dc.type	info:eu-repo/semantics/article
dc.identifier.doi	https://doi.org/10.1164/rccm.201709-1861OC
dc.subject.ocde	https://purl.org/pe-repo/ocde/ford#3.02.07
dc.subject.ocde	https://purl.org/pe-repo/ocde/ford#3.02.08
dc.relation.issn	1535-4970