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Axonal swellings and spheroids: a new insight into the pathology of neurocysticercosis

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dc.contributor.author Mejia Maza, Alan J.
dc.contributor.author Carmen-Orozco, Rogger P.
dc.contributor.author Carter, Emma
dc.contributor.author Dávila, Danitza G.
dc.contributor.author Castillo, Gino
dc.contributor.author Morales, Jemina D.
dc.contributor.author Mamani, Javier
dc.contributor.author Gavídia, Cesar
dc.contributor.author Alroy, Joseph
dc.contributor.author Sterling, Charles R.
dc.contributor.author Gonzalez, Armando E.
dc.contributor.author García, Héctor H.
dc.contributor.author Woltjer, Randy L.
dc.contributor.author Verástegui, Manuela R.
dc.contributor.author Gilman, Robert H.
dc.contributor.author Cysticercosis Working Group in Peru
dc.date.accessioned 2018-11-30T02:09:30Z
dc.date.available 2018-11-30T02:09:30Z
dc.date.issued 2018
dc.identifier.uri https://hdl.handle.net/20.500.12866/4012
dc.description.abstract Neurocysticercosis is a parasitic brain disease caused by the larval form (Cysticercus cellulosae) of the Taenia solium and is the leading cause of preventable epilepsy world-wide. However, the pathophysiology and relation to the wide range of clinical features remains poorly understood. Axonal swelling is emerging as an important early pathological finding in multiple neurodegenerative diseases and causes of brain injury, but has not been well-described in neurocysticercosis. Histological analysis was performed on human, rat and porcine NCC brain specimens to identify axonal pathology. Rat infection was successfully carried out via two routes of inoculation: direct intracranial injection and oral feeding. Extensive axonal swellings, in the form of spheroids, were observed in both humans and rats and to a lesser extent in pigs with NCC. Spheroids demonstrated increased immunoreactivity to amyloid precursor protein and neurofilament indicating probable impairment of axonal transport. These novel findings demonstrate that spheroids are present in NCC which is conserved across species. Not only is this an important contribution towards understanding that pathogenesis of NCC, but it also provides a model to analyze the association of spheroids with specific clinical features and to investigate the reversibility of spheroid formation with antihelmintic treatment. en_US
dc.language.iso eng
dc.publisher Wiley
dc.relation.ispartof urn:issn:1750-3639
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject amyloid precursor protein en_US
dc.subject animal cell en_US
dc.subject animal experiment en_US
dc.subject animal model en_US
dc.subject animal tissue en_US
dc.subject APP en_US
dc.subject Article en_US
dc.subject astrocyte en_US
dc.subject brain disease en_US
dc.subject brain histology en_US
dc.subject brain tissue en_US
dc.subject controlled study en_US
dc.subject human en_US
dc.subject human tissue en_US
dc.subject immunohistochemistry en_US
dc.subject immunoreactivity en_US
dc.subject meninx en_US
dc.subject microglia en_US
dc.subject nerve fiber degeneration en_US
dc.subject neurocysticercosis en_US
dc.subject neurofilament en_US
dc.subject neuropathology en_US
dc.subject nonhuman en_US
dc.subject oncosphere en_US
dc.subject parenchyma en_US
dc.subject phagocyte en_US
dc.subject pig en_US
dc.subject rat en_US
dc.subject spheroid cell en_US
dc.subject spheroids en_US
dc.subject T. solium oncospheres en_US
dc.subject Taenia solium en_US
dc.title Axonal swellings and spheroids: a new insight into the pathology of neurocysticercosis en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1111/bpa.12669
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.00 es_PE
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.01.09
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.01.04

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