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Backbone chemical shift assignment of macrophage infectivity potentiator virulence factor of Trypanosoma cruzi

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dc.contributor.author Lopez, Juan M.
dc.contributor.author Antiparra, Ricardo
dc.contributor.author Lippens, Guy
dc.contributor.author Zimic, Mirko
dc.contributor.author Sheen, Patricia
dc.contributor.author Maruenda, Helena
dc.date.accessioned 2018-11-30T02:09:30Z
dc.date.available 2018-11-30T02:09:30Z
dc.date.issued 2018
dc.identifier.uri https://hdl.handle.net/20.500.12866/4013
dc.description.abstract Chagas disease is a trypanosomiasis disease inflicted by Trypanosoma cruzi parasite. In Latin America, at least 10 million people are infected and annually, 10,000 casualties are deplored. Macrophage infectivity potentiator protein is one of the major virulence factors secreted by T. cruzi (TcMIP) in order to infect its host but little is known about its mechanism of action. Studies confer TcMIP an important role in the extracellular matrix transmigration and basal lamina penetration. Here, we report the backbone 1H, 13C, and 15N resonance assignment of TcMIP and the comparison of the secondary structure obtained against reported X-ray crystallography data. en_US
dc.language.iso eng
dc.publisher Springer
dc.relation.ispartof urn:issn:1874-270X
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Trypanosoma cruzi en_US
dc.subject FK506 binding protein en_US
dc.subject FKBP-like protein en_US
dc.subject Macrophage infectivity potentiator en_US
dc.subject NMR resonance assignment en_US
dc.subject Prolyl cis trans isomerase en_US
dc.subject TcMIP en_US
dc.subject Virulence factor en_US
dc.title Backbone chemical shift assignment of macrophage infectivity potentiator virulence factor of Trypanosoma cruzi en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1007/s12104-018-9844-1
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.00 es_PE

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