Bioimpedance markers and tuberculosis outcome among HIV-infected patients

Montalvo, Raúl; Gilman, Robert Hugh; Kirwan, Daniela E.; Bernabé Ortiz, Antonio

dc.contributor.author	Montalvo, Raúl
dc.contributor.author	Bernabé Ortiz, Antonio
dc.contributor.author	Kirwan, Daniela E.
dc.contributor.author	Gilman, Robert Hugh
dc.date.accessioned	2018-11-30T02:09:30Z
dc.date.available	2018-11-30T02:09:30Z
dc.date.issued	2018
dc.identifier.uri	https://hdl.handle.net/20.500.12866/4015
dc.description.abstract	Background: The changes in body composition markers (weight, fat mass, lean mass, and BMI) over time can be associated with TB treatment outcome among HIV-infected patients. The aim of this study was to investigate whether changes in fat mass and lean mass were associated with the treatment response among patients with HIV infection and pulmonary tuberculosis. Materials and Methods: This was a prospective cohort study. Data from HIV-infected patients commencing TB therapy were analyzed. This included body weight measurement using bioimpedance equipment at baseline, one month, and two months after starting TB treatment. Results: The study was conducted in 125 patients, 17 patients (13.6%) died during treatment, of which 5 died during the first month of treatment, 4 during the second month and 8 after the second month. The group of patients with good response, increased their weight by 1.3 kg (p <0.001) at the end of the first month of TB treatment and 2.6 kg in the second month (p <0.001), and body fat increase was 1.2 Kg (p <0.001) and 2.3 kg (p <0.001), the first and second month respectively. The group of patients who died had lost 2.1 kg fat mass after the first month (p <0.001) and 3.7 kg in the second month (p <0.001). Conclusions: Our results show that the weight change during TB treatment (increased fat mass) helps us predict therapeutic response. Weight loss during the first month of starting therapy should be evaluated thoroughly to identify the probable cause of treatment failure.	en_US
dc.language.iso	eng
dc.publisher	African Traditional Herbal Medicine Supporters Initiative
dc.relation.ispartofseries	African Journal of Infectious Diseases
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.rights.uri	https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject	tuberculosis	en_US
dc.subject	bio impedance	en_US
dc.subject	body weight gain	en_US
dc.subject	HIV / AIDS	en_US
dc.title	Bioimpedance markers and tuberculosis outcome among HIV-infected patients	en_US
dc.type	info:eu-repo/semantics/article
dc.identifier.doi	https://doi.org/10.21010/ajid.v12i2.8
dc.subject.ocde	https://purl.org/pe-repo/ocde/ford#3.03.08
dc.relation.issn	2505-0419