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Clinical topography relationship in patients with parenchymal neurocysticercosis and seizures

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dc.contributor.author Duque, Kevin R.
dc.contributor.author Escalaya, Alejandro L.
dc.contributor.author Zapata, Willy
dc.contributor.author Burneo, Jorge G.
dc.contributor.author Bustos Palomino, Javier Arturo
dc.contributor.author Gonzales, Isidro
dc.contributor.author Saavedra Pastor, Herbert
dc.contributor.author Pretell, E. Javier
dc.contributor.author García Lescano, Héctor Hugo
dc.contributor.author Cysticercosis Working Group in Peru
dc.date.accessioned 2018-11-30T02:09:31Z
dc.date.available 2018-11-30T02:09:31Z
dc.date.issued 2018
dc.identifier.uri https://hdl.handle.net/20.500.12866/4028
dc.description.abstract OBJECTIVE: Discordances between imaging findings of parenchymal neurocysticercosis and seizure expression have been reported, and as such the possibility that neurocysticercosis and seizures may frequently coexist by chance has been raised. In this study, we evaluate the topographic relationship between seizure foci based on semiology and electroencephalography with the location of parenchymal neurocysticercotic lesions. METHODS: Seizure information, neuroimaging (computed tomography and magnetic resonance imaging [MRI]) and electroencephalographic data from three randomized clinical trials of individuals with parenchymal neurocysticercosis and focal seizures were analyzed. Blinded epileptologists defined a potential seizure onset zone and a symptomatogenic zone for each individual based on semiology. The topographic relationship between semiology, either lesion location or areas of perilesional edema on baseline MRI, and electroencephalographic abnormalities were assessed. RESULTS: Fifty-eight patients with one or two parenchymal neurocysticercotic lesions were included in this study. From them, 50 patients (86%; 95% CI, 75%-93%) showed a clinical-topography relationship with the potential seizure onset zone, and 44 (76%) also with the symptomatogenic zone. From the eight patients with no topographic relationship, five had focal seizures 30 days before or after the baseline MRI and showed perilesional edema. All of these five patients showed a clinical-topography relationship between such seizures and an area of perilesional edema, making a total of 55 patients (95%; 95% CI, 85%-99%) with clinical-topography relationship when perilesional edema is considered. Most patients with focal epileptiform discharges (7/8, 88%) had a topographic association between electroencephalographic focality, the potential seizure onset zone and a cysticercotic lesion. CONCLUSION: Seizure semiology and focal epileptiform discharges are topographically related to neurocysticercotic lesions in most patients. These data strongly support seizure origin in the cortex surrounding these lesions. en_US
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartofseries Epilepsy research
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Peru en_US
dc.subject Neurocysticercosis en_US
dc.subject Cysticercosis en_US
dc.subject Epilepsy en_US
dc.subject Taenia solium en_US
dc.subject Seizures en_US
dc.title Clinical topography relationship in patients with parenchymal neurocysticercosis and seizures en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1016/j.eplepsyres.2018.06.011
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.25
dc.relation.issn 1872-6844


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