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Developmental pathways inferred from modularity, morphological integration and fluctuating asymmetry patterns in the human face

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dc.contributor.author Quinto-Sánchez, Mirsha
dc.contributor.author Muñoz-Muñoz, Francesc
dc.contributor.author Gomez-Valdes, Jorge
dc.contributor.author Cintas, Celia
dc.contributor.author Navarro, Pablo
dc.contributor.author Cerqueira, Caio Cesar Silva de
dc.contributor.author Paschetta, Carolina
dc.contributor.author de Azevedo, Soledad
dc.contributor.author Ramallo, Virginia
dc.contributor.author Acuña-Alonzo, Victor
dc.contributor.author Adhikari, Kaustubh
dc.contributor.author Fuentes-Guajardo, Macarena
dc.contributor.author Hünemeier, Tábita
dc.contributor.author Everardo, Paola
dc.contributor.author de Avila, Francisco
dc.contributor.author Jaramillo, Claudia
dc.contributor.author Arias, Williams
dc.contributor.author Gallo, Carla
dc.contributor.author Poletti, Giovani
dc.contributor.author Bedoya, Gabriel
dc.contributor.author Bortolini, Maria Cátira
dc.contributor.author Canizales-Quinteros, Samuel
dc.contributor.author Rothhammer, Francisco
dc.contributor.author Rosique, Javier
dc.contributor.author Ruiz-Linares, Andres
dc.contributor.author Gonzalez-Jose, Rolando
dc.date.accessioned 2018-11-30T03:10:44Z
dc.date.available 2018-11-30T03:10:44Z
dc.date.issued 2018
dc.identifier.uri https://hdl.handle.net/20.500.12866/4041
dc.description.abstract Facial asymmetries are usually measured and interpreted as proxies to developmental noise. However, analyses focused on its developmental and genetic architecture are scarce. To advance on this topic, studies based on a comprehensive and simultaneous analysis of modularity, morphological integration and facial asymmetries including both phenotypic and genomic information are needed. Here we explore several modularity hypotheses on a sample of Latin American mestizos, in order to test if modularity and integration patterns differ across several genomic ancestry backgrounds. To do so, 4104 individuals were analyzed using 3D photogrammetry reconstructions and a set of 34 facial landmarks placed on each individual. We found a pattern of modularity and integration that is conserved across sub-samples differing in their genomic ancestry background. Specifically, a signal of modularity based on functional demands and organization of the face is regularly observed across the whole sample. Our results shed more light on previous evidence obtained from Genome Wide Association Studies performed on the same samples, indicating the action of different genomic regions contributing to the expression of the nose and mouth facial phenotypes. Our results also indicate that large samples including phenotypic and genomic metadata enable a better understanding of the developmental and genetic architecture of craniofacial phenotypes. en_US
dc.language.iso eng
dc.publisher Springer
dc.relation.ispartof urn:issn:2045-2322
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject UNAVAILABLE en_US
dc.title Developmental pathways inferred from modularity, morphological integration and fluctuating asymmetry patterns in the human face en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1038/s41598-018-19324-y
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.00 es_PE

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