Epidemiology of Sapovirus Infections in a Birth Cohort in Peru

Sánchez, Gerardo J.; Gilman, Robert Hugh; Bern, Caryn; Crabtree, Jean E.; Saito, Mayuko; Mayta, Holger; Xiaofang, Liu; Oshitani, Hitoshi; Ballard, Sarah Blythe; Cama, Vitaliano; Pajuelo Travezaño, Monica Jhenny; Kelleher, Dermot; Neira, Karen; Cabrera, Lilia; Sapovirus Working Group

dc.contributor.author	Sánchez, Gerardo J.
dc.contributor.author	Mayta, Holger
dc.contributor.author	Pajuelo Travezaño, Monica Jhenny
dc.contributor.author	Neira, Karen
dc.contributor.author	Xiaofang, Liu
dc.contributor.author	Cabrera, Lilia
dc.contributor.author	Ballard, Sarah Blythe
dc.contributor.author	Crabtree, Jean E.
dc.contributor.author	Kelleher, Dermot
dc.contributor.author	Cama, Vitaliano
dc.contributor.author	Bern, Caryn
dc.contributor.author	Oshitani, Hitoshi
dc.contributor.author	Gilman, Robert Hugh
dc.contributor.author	Saito, Mayuko
dc.contributor.author	Sapovirus Working Group
dc.date.accessioned	2018-11-30T03:10:45Z
dc.date.available	2018-11-30T03:10:45Z
dc.date.issued	2018
dc.identifier.uri	https://hdl.handle.net/20.500.12866/4057
dc.description.abstract	Background: Sapovirus is one of the primary viral causes of acute gastroenteritis (AGE), especially where rotavirus vaccination has been implemented. The characteristics and impact of natural infection at the community level, however, have not been well documented. Methods: Stool samples were analyzed from 100 children randomly selected from a community-based birth cohort study in Peru. All diarrheal and 1 nondiarrheal stools collected trimonthly from children up to age 2 years (n = 1669) were tested for sapovirus detection. Viral shedding duration was determined by testing additional weekly samples (n = 440) collected before and after a sapovirus-positive sample. Results: The incidence of sapovirus infection in the first and second years of life was 4.3 and 11.1 per 100 child-months, respectively. By age 2 years, 82% of children had at least 1 sapovirus infection, and 64% had at least 1 sapovirus-associated diarrhea episode. The median shedding period was 18.5 days. In 112 of 175 infections, 14 genotypes from 4 genogroups (GI, GII, GIV, and GV) were determined. Among genogroups, GI were more frequently found in symptomatic infections than in asymptomatic infections (odds ratio, 3.1; 95% confidence interval, 1.3-7.4). Fifty-nine children had serial sapovirus infections, but only 3 had repeated infection of the same genotype. Conclusions: Sapovirus was frequently detected in children with AGE at the community level during the first 2 years of life. Serial sapovirus infections by multiple genotypes in a child suggest genotype-specific immunity from each infection, which needs to be taken into account for vaccine development.	en_US
dc.language.iso	eng
dc.publisher	Oxford University Press
dc.relation.ispartofseries	Clinical Infectious Diseases
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.rights.uri	https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject	sapovirus	en_US
dc.subject	birth cohort	en_US
dc.subject	diarrhea	en_US
dc.subject	gastroenteritis	en_US
dc.subject	epidemiology	en_US
dc.title	Epidemiology of Sapovirus Infections in a Birth Cohort in Peru	en_US
dc.type	info:eu-repo/semantics/article
dc.identifier.doi	https://doi.org/10.1093/cid/cix1103
dc.subject.ocde	https://purl.org/pe-repo/ocde/ford#3.03.08
dc.relation.issn	1537-6591