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Epidemiology of Sapovirus Infections in a Birth Cohort in Peru

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dc.contributor.author Sánchez, Gerardo J.
dc.contributor.author Mayta, Holger
dc.contributor.author Pajuelo, Monica J.
dc.contributor.author Neira, Karen
dc.contributor.author Xiaofang, Liu
dc.contributor.author Cabrera, Lilia
dc.contributor.author Ballard, Sarah Blythe
dc.contributor.author Crabtree, Jean E.
dc.contributor.author Kelleher, Dermot
dc.contributor.author Cama, Vitaliano
dc.contributor.author Bern, Caryn
dc.contributor.author Oshitani, Hitoshi
dc.contributor.author Gilman, Robert H.
dc.contributor.author Saito, Mayuko
dc.contributor.author Sapovirus Working Group
dc.date.accessioned 2018-11-30T03:10:45Z
dc.date.available 2018-11-30T03:10:45Z
dc.date.issued 2018
dc.identifier.uri https://hdl.handle.net/20.500.12866/4057
dc.description.abstract Background: Sapovirus is one of the primary viral causes of acute gastroenteritis (AGE), especially where rotavirus vaccination has been implemented. The characteristics and impact of natural infection at the community level, however, have not been well documented. Methods: Stool samples were analyzed from 100 children randomly selected from a community-based birth cohort study in Peru. All diarrheal and 1 nondiarrheal stools collected trimonthly from children up to age 2 years (n = 1669) were tested for sapovirus detection. Viral shedding duration was determined by testing additional weekly samples (n = 440) collected before and after a sapovirus-positive sample. Results: The incidence of sapovirus infection in the first and second years of life was 4.3 and 11.1 per 100 child-months, respectively. By age 2 years, 82% of children had at least 1 sapovirus infection, and 64% had at least 1 sapovirus-associated diarrhea episode. The median shedding period was 18.5 days. In 112 of 175 infections, 14 genotypes from 4 genogroups (GI, GII, GIV, and GV) were determined. Among genogroups, GI were more frequently found in symptomatic infections than in asymptomatic infections (odds ratio, 3.1; 95% confidence interval, 1.3-7.4). Fifty-nine children had serial sapovirus infections, but only 3 had repeated infection of the same genotype. Conclusions: Sapovirus was frequently detected in children with AGE at the community level during the first 2 years of life. Serial sapovirus infections by multiple genotypes in a child suggest genotype-specific immunity from each infection, which needs to be taken into account for vaccine development. en_US
dc.language.iso eng
dc.publisher Oxford University Press
dc.relation.ispartof urn:issn:1537-6591
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject UNAVAILABLE en_US
dc.title Epidemiology of Sapovirus Infections in a Birth Cohort in Peru en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1093/cid/cix1103
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.00 es_PE


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