Exhaled Nitric Oxide is Not a Biomarker for Pulmonary Tuberculosis

Clark, Taryn; Gilman, Robert Hugh; Loader, Maria-Cristina I.; López, José W.; Pastorius, Daniel; Romero Rivero, Karina Maribel; Friedland, Jon S.; Caviedes, Luz; Smith, Daniel; Checkley, William; Ticona, Eduardo; Bravard, Marjory

dc.contributor.author	López, José W.
dc.contributor.author	Loader, Maria-Cristina I.
dc.contributor.author	Smith, Daniel
dc.contributor.author	Pastorius, Daniel
dc.contributor.author	Bravard, Marjory
dc.contributor.author	Caviedes, Luz
dc.contributor.author	Romero Rivero, Karina Maribel
dc.contributor.author	Clark, Taryn
dc.contributor.author	Checkley, William
dc.contributor.author	Ticona, Eduardo
dc.contributor.author	Friedland, Jon S.
dc.contributor.author	Gilman, Robert Hugh
dc.date.accessioned	2018-11-30T03:10:46Z
dc.date.available	2018-11-30T03:10:46Z
dc.date.issued	2018
dc.identifier.uri	https://hdl.handle.net/20.500.12866/4067
dc.description.abstract	To reduce transmission of tuberculosis (TB) in resource-limited countries where TB remains a major cause of mortality, novel diagnostic tools are urgently needed. We evaluated the fractional concentration of exhaled nitric oxide (FeNO) as an easily measured, noninvasive potential biomarker for diagnosis and monitoring of treatment response in participants with pulmonary TB including multidrug resistant-TB in Lima, Peru. In a longitudinal study however, we found no differences in baseline median FeNO levels between 38 TB participants and 93 age-matched controls (13 parts per billion [ppb] [interquartile range (IQR) = 8-26] versus 15 ppb [IQR = 12-24]), and there was no change over 60 days of treatment (15 ppb [IQR = 10-19] at day 60). Taking this and previous evidence together, we conclude FeNO is not of value in either the diagnosis of pulmonary TB or as a marker of treatment response.	en_US
dc.language.iso	eng
dc.publisher	American Society of Tropical Medicine and Hygiene
dc.relation.ispartofseries	American Journal of Tropical Medicine and Hygiene (ASTMH Journal)
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.subject	Exhaled Nitric Oxide	en_US
dc.subject	Biomarker	en_US
dc.subject	Pulmonary Tuberculosis	en_US
dc.title	Exhaled Nitric Oxide is Not a Biomarker for Pulmonary Tuberculosis	en_US
dc.type	info:eu-repo/semantics/article
dc.identifier.doi	https://doi.org/10.4269/ajtmh.17-0425
dc.subject.ocde	https://purl.org/pe-repo/ocde/ford#3.03.06
dc.relation.issn	1476-1645