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Exhaled Nitric Oxide is Not a Biomarker for Pulmonary Tuberculosis

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dc.contributor.author López, José W.
dc.contributor.author Loader, Maria-Cristina I.
dc.contributor.author Smith, Daniel
dc.contributor.author Pastorius, Daniel
dc.contributor.author Bravard, Marjory
dc.contributor.author Caviedes, Luz
dc.contributor.author Romero, Karina M.
dc.contributor.author Clark, Taryn
dc.contributor.author Checkley, William
dc.contributor.author Ticona, Eduardo
dc.contributor.author Friedland, Jon S.
dc.contributor.author Gilman, Robert H.
dc.date.accessioned 2018-11-30T03:10:46Z
dc.date.available 2018-11-30T03:10:46Z
dc.date.issued 2018
dc.identifier.uri https://hdl.handle.net/20.500.12866/4067
dc.description.abstract To reduce transmission of tuberculosis (TB) in resource-limited countries where TB remains a major cause of mortality, novel diagnostic tools are urgently needed. We evaluated the fractional concentration of exhaled nitric oxide (FeNO) as an easily measured, noninvasive potential biomarker for diagnosis and monitoring of treatment response in participants with pulmonary TB including multidrug resistant-TB in Lima, Peru. In a longitudinal study however, we found no differences in baseline median FeNO levels between 38 TB participants and 93 age-matched controls (13 parts per billion [ppb] [interquartile range (IQR) = 8-26] versus 15 ppb [IQR = 12-24]), and there was no change over 60 days of treatment (15 ppb [IQR = 10-19] at day 60). Taking this and previous evidence together, we conclude FeNO is not of value in either the diagnosis of pulmonary TB or as a marker of treatment response. en_US
dc.language.iso eng
dc.publisher American Society of Tropical Medicine and Hygiene
dc.relation.ispartof urn:issn:1476-1645
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject UNAVAILABLE en_US
dc.title Exhaled Nitric Oxide is Not a Biomarker for Pulmonary Tuberculosis en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.4269/ajtmh.17-0425
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.06 es_PE
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.06

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