Universidad Peruana Cayetano Heredia

Hematopoietic Stem Cells but Not Multipotent Progenitors Drive Erythropoiesis during Chronic Erythroid Stress in EPO Transgenic Mice

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dc.contributor.author Singh, Rashim Pal
dc.contributor.author Grinenko, Tatyana
dc.contributor.author Ramasz, Beáta
dc.contributor.author Franke, Kristin
dc.contributor.author Lesche, Mathias
dc.contributor.author Dahl, Andreas
dc.contributor.author Gassmann, Max
dc.contributor.author Chavakis, Triantafyllos
dc.contributor.author Henry, Ian
dc.contributor.author Wielockx, Ben
dc.date.accessioned 2018-11-30T17:17:12Z
dc.date.available 2018-11-30T17:17:12Z
dc.date.issued 2018
dc.identifier.uri https://hdl.handle.net/20.500.12866/4086
dc.description.abstract The hematopoietic stem cell (HSC) compartment consists of a small pool of cells capable of replenishing all blood cells. Although it is established that the hematopoietic system is assembled as a hierarchical organization under steady-state conditions, emerging evidence suggests that distinct differentiation pathways may exist in response to acute stress. However, it remains unclear how different hematopoietic stem and progenitor cell subpopulations behave under sustained chronic stress. Here, by using adult transgenic mice overexpressing erythropoietin (EPO; Tg6) and a combination of in vivo, in vitro, and deep-sequencing approaches, we found that HSCs respond differentially to chronic erythroid stress compared with their closely related multipotent progenitors (MPPs). Specifically, HSCs exhibit a vastly committed erythroid progenitor profile with enhanced cell division, while MPPs display erythroid and myeloid cell signatures and an accumulation of uncommitted cells. Thus, our results identify HSCs as master regulators of chronic stress erythropoiesis, potentially circumventing the hierarchical differentiation-detour. en_US
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartofseries Stem Cell Reports
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject hypoxia en_US
dc.subject bone marrow en_US
dc.subject EPO-R en_US
dc.subject erythropoietin en_US
dc.subject fate decision en_US
dc.subject hematopoietic stem cell en_US
dc.subject progenitors en_US
dc.subject transgenic en_US
dc.title Hematopoietic Stem Cells but Not Multipotent Progenitors Drive Erythropoiesis during Chronic Erythroid Stress in EPO Transgenic Mice en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1016/j.stemcr.2018.04.012
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#1.06.03
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#1.06.01
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#1.06.07
dc.relation.issn 2213-6711


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