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Human and Equine Infection with Alphaviruses and Flaviviruses in Panamá during 2010: A Cross-Sectional Study of Household Contacts during an Encephalitis Outbreak

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dc.contributor.author Carrera, Jean-Paul
dc.contributor.author Bagamian, Karoun H.
dc.contributor.author Travassos da Rosa, Amelia P.
dc.contributor.author Wang, Eryu
dc.contributor.author Beltran, Davis
dc.contributor.author Gundaker, Nathan D.
dc.contributor.author Armien, Blas
dc.contributor.author Arroyo, Gianfranco
dc.contributor.author Sosa, Néstor
dc.contributor.author Pascale, Juan Miguel
dc.contributor.author Valderrama, Anayansi
dc.contributor.author Tesh, Robert B.
dc.contributor.author Vittor, Amy Y.
dc.contributor.author Weaver, Scott C.
dc.date.accessioned 2018-11-30T17:17:13Z
dc.date.available 2018-11-30T17:17:13Z
dc.date.issued 2018
dc.identifier.uri https://hdl.handle.net/20.500.12866/4091
dc.description.abstract Members of the genera Alphavirus (family Togaviridae) and Flavivirus (family Flaviridae) are important zoonotic human and equine etiologic agents of neurologic diseases in the New World. In 2010, an outbreak of Madariaga virus (MADV; formerly eastern equine encephalitis virus) and Venezuelan equine encephalitis virus (VEEV) infections was reported in eastern Panamá. We further characterized the epidemiology of the outbreak by studying household contacts of confirmed human cases and of equine cases with neurological disease signs. Serum samples were screened using a hemagglutination inhibition test, and human results were confirmed using plaque reduction neutralization tests. A generalized linear model was used to evaluate the human MADV and VEEV seroprevalence ratios by age (in tercile) and gender. Overall, antibody prevalence for human MADV infection was 19.4%, VEEV 33.3%, and Mayaro virus 1.4%. In comparison with individuals aged 2-20 years, people from older age groups (21-41 and > 41 years) were five times more likely to have antibodies against VEEV, whereas the MADV prevalence ratio was independent of age. The overall seroprevalence of MADV in equids was 26.3%, VEEV 29.4%, West Nile virus (WNV) 2.6%, and St. Louis encephalitis virus (SLEV) was 63.0%. Taken together, our results suggest that multiple arboviruses are circulating in human and equine populations in Panamá. Our findings of a lack of increase in the seroprevalence ratio with age support the hypothesis of recent MADV exposure to people living in the affected region. en_US
dc.language.iso eng
dc.publisher American Society of Tropical Medicine and Hygiene
dc.relation.ispartof urn:issn:0002-9637
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject UNAVAILABLE en_US
dc.title Human and Equine Infection with Alphaviruses and Flaviviruses in Panamá during 2010: A Cross-Sectional Study of Household Contacts during an Encephalitis Outbreak en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.4269/ajtmh.17-0679
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.06 es_PE


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