Individual and Spatial Risk of Dengue Virus Infection in Puerto Maldonado, Peru

Salmón-Mulanovich, Gabriela; Rios, Zonia; Espinoza, Angelica; Montgomery, Joel M.; Lescano Guevara, Andres Guillermo; Guevara, Carolina; Pan, William K.; Bausch, Daniel G.; Blazes, David L.; Guezala V, M. Claudia

dc.contributor.author	Salmón-Mulanovich, Gabriela
dc.contributor.author	Blazes, David L.
dc.contributor.author	Guezala V, M. Claudia
dc.contributor.author	Rios, Zonia
dc.contributor.author	Espinoza, Angelica
dc.contributor.author	Guevara, Carolina
dc.contributor.author	Lescano Guevara, Andres Guillermo
dc.contributor.author	Montgomery, Joel M.
dc.contributor.author	Bausch, Daniel G.
dc.contributor.author	Pan, William K.
dc.date.accessioned	2018-11-30T17:17:13Z
dc.date.available	2018-11-30T17:17:13Z
dc.date.issued	2018
dc.identifier.uri	https://hdl.handle.net/20.500.12866/4098
dc.description.abstract	Dengue virus (DENV) affects more than 100 countries worldwide. Dengue virus infection has been increasing in the southern Peruvian Amazon city of Puerto Maldonado since 2000. We designed this study to describe the prevalence of past DENV infection and to evaluate risk factors. In 2012, we conducted a cross-sectional serosurvey and administered a knowledge, attitudes, and practices (KAP) questionnaire to members of randomly selected households. Sera were screened for antibodies to DENV by ELISA and confirmed by plaque reduction neutralization test. We created indices for KAP (KAPi). We used SaTScan to detect clustering and created a multivariate model introducing the distance of households to potential vector and infection sources. A total of 505 participants from 307 households provided a blood sample and completed a questionnaire. Fifty-four percent of participants (95% CI: 49.6; 58.5) had neutralizing antibodies to DENV. Higher values of KAPi were positively associated with having DENV antibodies in the multivariate analysis (odds ratio [ORII]: 1.6, 95% CI: 0.6, 2.4; ORIII: 2.7, 95% CI: 1.3, 5.5; and ORIV: 2.4, 95% CI: 1.2, 5.0). Older groups had lower chances of having been exposed to DENV than younger people (OR20-30: 0.5, 95% CI: 0.2, 0.8; OR31-45: 0.5, 95% CI: 0.3, 0.9; and OR>45: 0.6, 95% CI: 0.3, 1.3). Multivariate data analysis from the 270 households with location information showed male gender to have lower risk of past DENV infection (OR: 0.6, 95% CI: 0.4, 0.9). We conclude that risk of DENV infection in Puerto Maldonado is related to gender, age of the population, and location.	en_US
dc.language.iso	eng
dc.publisher	American Society of Tropical Medicine and Hygiene
dc.relation.ispartofseries	American Journal of Tropical Medicine and Hygiene (ASTMH Journal)
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.subject	IndividualSpatial Risk	en_US
dc.subject	Dengue Virus	en_US
dc.subject	Puerto Maldonado	en_US
dc.subject	Peru	en_US
dc.title	Individual and Spatial Risk of Dengue Virus Infection in Puerto Maldonado, Peru	en_US
dc.type	info:eu-repo/semantics/article
dc.identifier.doi	https://doi.org/10.4269/ajtmh.17-1015
dc.subject.ocde	https://purl.org/pe-repo/ocde/ford#3.03.06
dc.relation.issn	1476-1645