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Inflammation is a key risk factor for persistent seizures in neurocysticercosis

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dc.contributor.author Herrick, Jesica A.
dc.contributor.author Maharathi, Biswajit
dc.contributor.author Kim, Jin Suh
dc.contributor.author Abundis, Gerardo G.
dc.contributor.author Garg, Anjali
dc.contributor.author Gonzales, Isidro
dc.contributor.author Saavedra, Herbert
dc.contributor.author Bustos, Javier A.
dc.contributor.author Garcia, Hector H.
dc.contributor.author Loeb, Jeffrey A.
dc.contributor.author Cysticercosis Working Group in Peru
dc.date.accessioned 2018-11-30T17:17:14Z
dc.date.available 2018-11-30T17:17:14Z
dc.date.issued 2018
dc.identifier.uri https://hdl.handle.net/20.500.12866/4100
dc.description.abstract Objective: We conducted a retrospective, case-control study of neurocysticercosis patients to ascertain early markers that identify subjects likely to develop treatment-resistant seizures. Methods: Clinical histories and imaging studies from 38 neurocysticercosis patients who had been followed for 18 months after treatment were evaluated. Both pairwise and multifactorial analyses were conducted to identify factors associated with continued seizures. Results: Eleven of 38 patients continued to have seizures during the follow-up period. On univariate analysis, the number of neurocysticercosis lesions, number of bands on the baseline neurocysticercosis western blot, edema volumes on follow-up MRI scans, edema volume changes between baseline and follow-up images, and proportion of calcified lesions with perilesional edema were all significantly increased in subjects who had persistent seizures during the 18-month follow-up period. On multivariate analyses using recursive partition and random forest algorithms, variables associated with persistent seizures included: the number of total and calcified lesions, presence of perilesional edema, the rate of change in the lesion and edema volumes from baseline to follow-up, and the number of bands on the neurocysticercosis western blot. Interpretation: Measures of both inflammation and disease burden are key risk factors for persistent seizures despite anticonvulsant treatments in patients with neurocysticercosis. Inflammation is therefore a potentially modifiable risk factor for the frequently seen severe seizure disorders in patients with neurocysticercosis. en_US
dc.language.iso eng
dc.publisher Wiley
dc.relation.ispartof urn:issn:2328-9503
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject UNAVAILABLE en_US
dc.title Inflammation is a key risk factor for persistent seizures in neurocysticercosis en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1002/acn3.562
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.00 es_PE
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.25


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