Inflammation is a key risk factor for persistent seizures in neurocysticercosis

Maharathi, Biswajit; Gonzales, Isidro; Garg, Anjali; García Lescano, Héctor Hugo; Kim, Jin Suh; Abundis, Gerardo G.; Bustos Palomino, Javier Arturo; Loeb, Jeffrey A.; Cysticercosis Working Group in Peru; Herrick, Jesica A.; Saavedra Pastor, Herbert

dc.contributor.author	Herrick, Jesica A.
dc.contributor.author	Maharathi, Biswajit
dc.contributor.author	Kim, Jin Suh
dc.contributor.author	Abundis, Gerardo G.
dc.contributor.author	Garg, Anjali
dc.contributor.author	Gonzales, Isidro
dc.contributor.author	Saavedra Pastor, Herbert
dc.contributor.author	Bustos Palomino, Javier Arturo
dc.contributor.author	García Lescano, Héctor Hugo
dc.contributor.author	Loeb, Jeffrey A.
dc.contributor.author	Cysticercosis Working Group in Peru
dc.date.accessioned	2018-11-30T17:17:14Z
dc.date.available	2018-11-30T17:17:14Z
dc.date.issued	2018
dc.identifier.uri	https://hdl.handle.net/20.500.12866/4100
dc.description.abstract	Objective: We conducted a retrospective, case-control study of neurocysticercosis patients to ascertain early markers that identify subjects likely to develop treatment-resistant seizures. Methods: Clinical histories and imaging studies from 38 neurocysticercosis patients who had been followed for 18 months after treatment were evaluated. Both pairwise and multifactorial analyses were conducted to identify factors associated with continued seizures. Results: Eleven of 38 patients continued to have seizures during the follow-up period. On univariate analysis, the number of neurocysticercosis lesions, number of bands on the baseline neurocysticercosis western blot, edema volumes on follow-up MRI scans, edema volume changes between baseline and follow-up images, and proportion of calcified lesions with perilesional edema were all significantly increased in subjects who had persistent seizures during the 18-month follow-up period. On multivariate analyses using recursive partition and random forest algorithms, variables associated with persistent seizures included: the number of total and calcified lesions, presence of perilesional edema, the rate of change in the lesion and edema volumes from baseline to follow-up, and the number of bands on the neurocysticercosis western blot. Interpretation: Measures of both inflammation and disease burden are key risk factors for persistent seizures despite anticonvulsant treatments in patients with neurocysticercosis. Inflammation is therefore a potentially modifiable risk factor for the frequently seen severe seizure disorders in patients with neurocysticercosis.	en_US
dc.language.iso	eng
dc.publisher	Wiley
dc.relation.ispartofseries	Annals of Clinical and Translational Neurology
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.subject	Inflammation	en_US
dc.subject	risk factor	en_US
dc.subject	seizures	en_US
dc.subject	inneurocysticercosis	en_US
dc.title	Inflammation is a key risk factor for persistent seizures in neurocysticercosis	en_US
dc.type	info:eu-repo/semantics/article
dc.identifier.doi	https://doi.org/10.1002/acn3.562
dc.subject.ocde	https://purl.org/pe-repo/ocde/ford#3.02.25
dc.relation.issn	2328-9503