Universidad Peruana Cayetano Heredia

Molecular Characterization of Tandem Repeat Protein 36 Gene of Ehrlichia canis Detected in Naturally Infected Dogs from Peru

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dc.contributor.author Geiger, Joseph
dc.contributor.author Morton, Bridget A.
dc.contributor.author Vasconcelos, Elton Jose Rosas
dc.contributor.author Tngrian, Maryam
dc.contributor.author Kachani, Malika
dc.contributor.author Barrón, Eduardo A.
dc.contributor.author Gavidia, Cesar M.
dc.contributor.author Gilman, Robert Hugh
dc.contributor.author Angulo, Noelia P.
dc.contributor.author Lerner, Richard
dc.contributor.author Scott, Tamerin
dc.contributor.author Mirrashed, N. Hannah
dc.contributor.author Oakley, Brian
dc.contributor.author Diniz, Pedro Paulo V. P.
dc.date.accessioned 2018-11-30T17:17:15Z
dc.date.available 2018-11-30T17:17:15Z
dc.date.issued 2018
dc.identifier.uri https://hdl.handle.net/20.500.12866/4122
dc.description.abstract Ehrlichia spp. are emerging infectious pathogens, especially in the Americas. Although Ehrlichia canis is primarily a parasite of dogs, polymerase chain reaction-confirmed human infections have been reported from Mexico, Venezuela, and Costa Rica. This study reports the presence of E. canis DNA in 13.7% of 205 dogs from urban areas in Peru and of those, five were analyzed for phylogenetic variation using the Tandem Repeat Protein 36 (TRP36) gene. The use of the TRP36 gene for such analysis was validated against 16S rRNA and heat shock protein genes using Shannon's entropy bioinformatic approach. When compared with other E. canis strains previously reported, three unique and novel E. canis strains were detected. In addition, the TRP36 amino acid tandem repeat sequences of the Peruvian strains share close similarity to an E. canis strain detected from four human blood bank samples in Costa Rica. This study reports for the first time domestic dogs infected with E. canis strains closely related to a zoonotic strain, which may be of public health concern as dogs can be chronically infected with this pathogen. en_US
dc.language.iso eng
dc.publisher American Society of Tropical Medicine and Hygiene
dc.relation.ispartofseries American Journal of Tropical Medicine and Hygiene (ASTMH Journal)
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Molecular Characterization en_US
dc.subject Protein 36 Gene en_US
dc.subject Ehrlichia canis en_US
dc.subject Dogs en_US
dc.subject Peru en_US
dc.title Molecular Characterization of Tandem Repeat Protein 36 Gene of Ehrlichia canis Detected in Naturally Infected Dogs from Peru en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.4269/ajtmh.17-0776
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.06
dc.relation.issn 1476-1645


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