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MPT64 patch test for the diagnosis of active pulmonary tuberculosis: a randomised controlled trial in Peru

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dc.contributor.author Pope, V.
dc.contributor.author Sacksteder, K. A.
dc.contributor.author Hererra, J. Coronel
dc.contributor.author Gilman, Robert Hugh
dc.contributor.author Vargas-Prada, S.
dc.contributor.author Lopez Romero, S.
dc.contributor.author Yafac, J.
dc.contributor.author Sanchez Rios, E.
dc.contributor.author Moore, David Alexander James
dc.date.accessioned 2018-11-30T17:17:16Z
dc.date.available 2018-11-30T17:17:16Z
dc.date.issued 2018
dc.identifier.uri https://hdl.handle.net/20.500.12866/4128
dc.description.abstract SETTING: There remains a lack of effective and inexpensive diagnostic tools for active tuberculosis (TB) disease. Testing immune responses to proteins secreted by Mycobacterium tuberculosis, such as MPT64, may be a diagnostic option. OBJECTIVE: To evaluate the sensitivity and specificity of a patch test using MPT64 for the diagnosis of active TB disease. DESIGN: This randomised, double-blind, placebo-controlled, prospective study in Lima, Peru, involved 55 healthy controls and 457 symptomatic individuals referred for routine TB testing by the National TB Control Programme. All subjects underwent a comprehensive diagnostic workup, and received an active patch on one arm and a placebo patch on the opposite arm, which were read after 4 days. RESULTS: Eighty-one (18%) of the symptomatic participants were classified as having definite TB, while an additional 98 (21%) had probable TB. The patch tests performed the same in both groups, with a sensitivity of 27% and specificity of 74%. The area under the receiver operating characteristic curve was 0.495 (95%CI 0.425-0.565). CONCLUSIONS: Contrary to existing literature, the MPT64 patch was not sensitive and specific to detect active TB. Given the potential of the test, understanding possible differences in the protein source or underlying genetic factors should be explored further. en_US
dc.language.iso eng
dc.publisher International Union Against Tuberculosis and Lung Disease
dc.relation.ispartofseries International Journal of Tuberculosis and Lung Disease
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject MPT64 en_US
dc.subject TB en_US
dc.subject diagnostic en_US
dc.subject patch test en_US
dc.title MPT64 patch test for the diagnosis of active pulmonary tuberculosis: a randomised controlled trial in Peru en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.5588/ijtld.17.0716
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.08
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.07
dc.relation.issn 1815-7920


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