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Patterns of Body Composition Relating to Chronic Respiratory Diseases Among Adults in Four Resource-Poor Settings in Peru

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dc.contributor.author Trompeter, Grace
dc.contributor.author Grigsby, Matthew R.
dc.contributor.author Miele, Catherine H.
dc.contributor.author Wise, Robert A.
dc.contributor.author Gilman, Robert Hugh
dc.contributor.author Miranda, J. Jaime
dc.contributor.author Bernabé Ortiz, Antonio
dc.contributor.author Checkley, William
dc.contributor.author CRONICAS Cohort Study Group
dc.date.accessioned 2018-11-30T22:50:35Z
dc.date.available 2018-11-30T22:50:35Z
dc.date.issued 2018
dc.identifier.uri https://hdl.handle.net/20.500.12866/4146
dc.description.abstract PURPOSE: Body composition is known to influence the development and progression of chronic respiratory diseases (CRDs). We sought to characterize the unique anthropometric phenotypes that present with asthma, chronic obstructive pulmonary disease (COPD), and chronic bronchitis across four distinct settings in Peru. METHODS: We collected sociodemographic, clinical history, and spirometry data from 2959 participants from Lima, Tumbes, and rural and urban Puno. We compared the prevalence of CRDs among different study sites and described disease phenotypes. We used single and multivariable linear regression to model the influence of CRD status on various descriptors of body composition. RESULTS: Overall prevalence of CRDs varied across sites with the highest prevalence of asthma in Lima (14.5%) and the highest prevalence of COPD in rural Puno (9.9%). Measures of body composition also varied across sites, with highest mean body mass index (BMI) in Lima (28.4 kg/m2) and the lowest mean BMI in rural Puno (25.2 kg/m2). Participants with COPD had the lowest mean fat mass index (FMI) (10.5 kg/m2) and waist circumference (88.3 cm), whereas participants with asthma had the highest mean FMI (14.5 kg/m2), and waist circumference (94.8 cm). In multivariable analysis, participants with COPD had a lower waist circumference (adjusted mean - 2.97 cm, 95% CI 4.62 to - 1.32 cm) when compared to non-CRD participants. CONCLUSIONS: Our findings provide evidence that asthma and chronic bronchitis are more likely to be associated with obesity and higher fat mass, while COPD is associated with being underweight and having less lean mass. en_US
dc.language.iso eng
dc.publisher Springer
dc.relation.ispartofseries Lung
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Asthma en_US
dc.subject Body composition en_US
dc.subject Body mass index (BMI) en_US
dc.subject Chronic bronchitis en_US
dc.subject Chronic disease en_US
dc.subject Chronic obstructive pulmonary disease (COPD) en_US
dc.subject Chronic respiratory disease en_US
dc.subject Fat free mass index (FFMI) en_US
dc.subject Fat mass index (FMI) en_US
dc.subject Waist circumference en_US
dc.title Patterns of Body Composition Relating to Chronic Respiratory Diseases Among Adults in Four Resource-Poor Settings in Peru en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1007/s00408-018-0109-7
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.07
dc.relation.issn 1432-1750

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