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Plagiochiline A Inhibits Cytokinetic Abscission and Induces Cell Death

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dc.contributor.author Stivers, Nicole S.
dc.contributor.author Islam, Ashraful
dc.contributor.author Reyes-Reyes, Elsa M.
dc.contributor.author Casson, Lavona K.
dc.contributor.author Aponte, José C.
dc.contributor.author Vaisberg Wollach, Abraham Jaime
dc.contributor.author Hammond, Gerald B.
dc.contributor.author Bates, Paula J.
dc.date.accessioned 2018-11-30T22:50:35Z
dc.date.available 2018-11-30T22:50:35Z
dc.date.issued 2018
dc.identifier.uri https://hdl.handle.net/20.500.12866/4151
dc.description.abstract We previously reported on the isolation and biological activities of plagiochiline A (1), a 2,3-secoaromadendrane-type sesquiterpenoid from the Peruvian medicinal plant, Plagiochila disticha. This compound was found to have antiproliferative effects on a variety of solid tumor cell lines, as well as several leukemia cell lines. Other researchers have also noted the cytotoxicity of plagiochiline A (isolated from different plant species), but there are no prior reports regarding the mechanism for this bioactivity. Here, we have evaluated the effects of plagiochiline A on cell cycle progression in DU145 prostate cancer cells. A cell cycle analysis indicated that plagiochiline A caused a significant increase in the percentage of cells in the G₂/M phase when compared with control cells. When cells were stained and observed by fluorescence microscopy to examine progress through the mitotic phase, we found a significant increase in the proportion of cells with features of late cytokinesis (cells connected by intercellular bridges) in the plagiochiline A-treated samples. These results suggest that plagiochiline A inhibits cell division by preventing completion of cytokinesis, particularly at the final abscission stage. We also determined that plagiochiline A reduces DU145 cell survival in clonogenic assays and that it induces substantial cell death in these cells. en_US
dc.language.iso eng
dc.publisher MDPI
dc.relation.ispartofseries Molecules
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Humans en_US
dc.subject Male en_US
dc.subject Plant Extracts en_US
dc.subject abscission en_US
dc.subject Cell Line, Tumor en_US
dc.subject Cell Proliferation en_US
dc.subject Cell Survival en_US
dc.subject cytokinesis en_US
dc.subject Cytokinesis en_US
dc.subject Embryophyta en_US
dc.subject Epoxy Compounds en_US
dc.subject Plagiochila disticha en_US
dc.subject plagiochiline A en_US
dc.subject Prostatic Neoplasms en_US
dc.subject Pyrans en_US
dc.title Plagiochiline A Inhibits Cytokinetic Abscission and Induces Cell Death en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.3390/molecules23061418
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#1.06.03
dc.relation.issn 1420-3049


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