Universidad Peruana Cayetano Heredia

Prevalence of and Factors Associated with Negative Microscopic Diagnosis of Cutaneous Leishmaniasis in Rural Peru

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dc.contributor.author Lamm, Ryan
dc.contributor.author Alves, Clark
dc.contributor.author Perrotta, Grace
dc.contributor.author Murphy, Meagan
dc.contributor.author Messina, Catherine
dc.contributor.author Sanchez, Juan F.
dc.contributor.author Perez, Erika
dc.contributor.author Rosales, Luis Angel
dc.contributor.author Lescano Guevara, Andres Guillermo
dc.contributor.author Smith, Edward
dc.contributor.author Valdivia, Hugo
dc.contributor.author Fuhrer, Jack
dc.contributor.author Ballard, Sarah-Blythe
dc.date.accessioned 2018-11-30T22:50:36Z
dc.date.available 2018-11-30T22:50:36Z
dc.date.issued 2018
dc.identifier.uri https://hdl.handle.net/20.500.12866/4157
dc.description.abstract Cutaneous leishmaniasis is endemic to South America where diagnosis is most commonly conducted via microscopy. Patients with suspected leishmaniasis were referred for enrollment by the Ministry of Health (MoH) in Lima, Iquitos, Puerto Maldonado, and several rural areas of Peru. A 43-question survey requesting age, gender, occupation, characterization of the lesion(s), history of leishmaniasis, and insect-deterrent behaviors was administered. Polymerase chain reaction (PCR) was conducted on lesion materials at the Naval Medical Research Unit No. 6 in Lima, and the results were compared with those obtained by the MoH using microscopy. Factors associated with negative microscopy and positive PCR results were identified using χ2 test, t-test, and multivariate logistic regression analyses. Negative microscopy with positive PCR occurred in 31% (123/403) of the 403 cases. After adjusting for confounders, binary multivariate logistic regression analyses revealed that negative microscopy with positive PCR was associated with patients who were male (adjusted odds ration [OR] = 1.93 [1.06-3.53], P = 0.032), had previous leishmaniasis (adjusted OR = 2.93 [1.65-5.22], P < 0.0001), had larger lesions (adjusted OR = 1.02 [1.003-1.03], P = 0.016), and/or had a longer duration between lesion appearance and PCR testing (adjusted OR = 1.12 [1.02-1.22], P = 0.017). Future research should focus on further exploration of these underlying variables, discovery of other factors that may be associated with negative microscopy diagnosis, and the development and implementation of improved testing in endemic regions. en_US
dc.language.iso eng
dc.publisher American Society of Tropical Medicine and Hygiene
dc.relation.ispartofseries American Journal of Tropical Medicine and Hygiene (ASTMH Journal)
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Negative Microscopic Diagnosis en_US
dc.subject Cutaneous Leishmaniasis en_US
dc.subject Rural en_US
dc.subject Peru en_US
dc.title Prevalence of and Factors Associated with Negative Microscopic Diagnosis of Cutaneous Leishmaniasis in Rural Peru en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.4269/ajtmh.17-0909
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.06
dc.relation.issn 1476-1645


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