Spontaneously Arrested Transmission of Cysticercosis in a Highly Endemic Village with a Very Low Migration Rate

Del Brutto, Oscar H.; O'Neal, Seth E.; García Lescano, Héctor Hugo; Dorny, Pierre

dc.contributor.author	Del Brutto, Oscar H.
dc.contributor.author	O'Neal, Seth E.
dc.contributor.author	Dorny, Pierre
dc.contributor.author	García Lescano, Héctor Hugo
dc.date.accessioned	2018-11-30T22:50:37Z
dc.date.available	2018-11-30T22:50:37Z
dc.date.issued	2018
dc.identifier.uri	https://hdl.handle.net/20.500.12866/4178
dc.description.abstract	Taenia solium cysticercosis is difficult to eliminate without interventions or societal development. Atahualpa is a rural Ecuadorian village with documented low migration rate, where domestic pig raising is common and human cysticercosis is endemic. To assess neurocysticercosis (NCC) prevalence, 1,273 villagers aged ≥ 20 years underwent neuroimaging studies, which showed calcified lesions in 121 (9.5%) individuals, but no active disease. Likewise, positive reactions, apparently nonspecific, were found in only 3/200 subjects by the use of a monoclonal antibody-based enzyme-linked immunosorbent assay to detect T. solium antigens in urine. Only 2/418 pigs reacted to three antibody bands on serum western blot and none to more than three bands. This is the first time that spontaneously arrested T. solium transmission is documented in a known endemic village. Understanding why active transmission stopped could provide insights on potential targets for control interventions. Atahualpa could provide an optimal scenario for longitudinal studies on the consequences of calcified NCC.	en_US
dc.language.iso	eng
dc.publisher	American Society of Tropical Medicine and Hygiene
dc.relation.ispartofseries	American Journal of Tropical Medicine and Hygiene (ASTMH Journal)
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.subject	Cysticercosis	en_US
dc.subject	Highly Endemic Village	en_US
dc.subject	Low Migration Rate	en_US
dc.title	Spontaneously Arrested Transmission of Cysticercosis in a Highly Endemic Village with a Very Low Migration Rate	en_US
dc.type	info:eu-repo/semantics/article
dc.identifier.doi	https://doi.org/10.4269/ajtmh.17-0723
dc.subject.ocde	https://purl.org/pe-repo/ocde/ford#3.03.06
dc.relation.issn	1476-1645