Universidad Peruana Cayetano Heredia

Th1/Th17/Th22 immune response and their association with joint pain, imagenological bone loss, RANKL expression and osteoclast activity in temporomandibular joint osteoarthritis: A preliminary report

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dc.contributor.author Monasterio, G.
dc.contributor.author Castillo, F.
dc.contributor.author Rojas, L.
dc.contributor.author Cafferata, E. A.
dc.contributor.author Alvarez, C.
dc.contributor.author Carvajal, P.
dc.contributor.author Núñez, C.
dc.contributor.author Flores, G.
dc.contributor.author Díaz, W.
dc.contributor.author Vernal, R.
dc.date.accessioned 2018-11-30T23:41:29Z
dc.date.available 2018-11-30T23:41:29Z
dc.date.issued 2018
dc.identifier.uri https://hdl.handle.net/20.500.12866/4185
dc.description.abstract It is well accepted that the presence of cytokines belonging to the Th1/Th17/Th22 axis of immuno-inflammatory response in the joint environment, such as IL-1β, IL-17 and IL-22, respectively, are associated with pathogenesis of several synovial joint degenerative disorders. During temporomandibular joint osteoarthritis (TMJ-OA), IL-1β and IL-17 have been implicated in the inflammation and resorption of sub-chondral bone; however, the role of Th22 response in the TMJ-OA pathophysiology has not been established. This study aimed to compare the expression of Th1/Th17/Th22-type cytokines, chemokines and chemokine receptors in synovial fluid samples obtained from TMJ-OA or disk displacement with reduction (DDWR) patients. In addition, it aimed to associate these levels with joint pain, imagenological signs of bone degeneration, RANKL production, osteoclastogenesis and osteoclast-induced bone resorption. Higher levels of IL-1β, IL-17 and IL-22 were expressed in TMJ-OA compared with DDWR subjects, and these increased levels significantly correlated with RANKL expression, joint pain and articular bone degeneration. Higher levels of CCR5, CCR6 and CCR7, as well as their respective ligands CCL5 and CCL20, responsible for recruitment of IL-1β, IL-17 and IL-22-producing cells, were over-expressed in TMJ-OA compared with DDWR subjects. Osteoclastogenesis and osteoclast-induced bone resorption were significantly greater in presence of synovial fluid from TMJ-OA compared with DDWR subjects. These data demonstrate that cytokines, CCLs and CCRs associated with the Th1/Th17/Th22 axis of immuno-inflammatory response are involved in TMJ-OA pathogenesis. These findings suggest that IL-22 is involved in the RANKL expression in TMJ-OA, which in turn induces differentiation of osteoclasts and subsequent resorption of sub-chondral bone. en_US
dc.language.iso eng
dc.publisher Wiley
dc.relation.ispartofseries Journal of Oral Rehabilitation
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject bone resorption en_US
dc.subject chemokines en_US
dc.subject cytokines en_US
dc.subject interleukin-22 en_US
dc.subject RANKL en_US
dc.subject temporomandibular osteoarthritis en_US
dc.title Th1/Th17/Th22 immune response and their association with joint pain, imagenological bone loss, RANKL expression and osteoclast activity in temporomandibular joint osteoarthritis: A preliminary report en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1111/joor.12649
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.14
dc.relation.issn 1365-2842


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