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A bibliometric analysis of the global research on biosimilars

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dc.contributor.author Hernández-Vásquez, A.
dc.contributor.author Alarcon-Ruiz, C.A.
dc.contributor.author Bendezu-Quispe, G.
dc.contributor.author Comandé, D.
dc.contributor.author Rosselli, D.
dc.date.accessioned 2018-11-30T23:41:31Z
dc.date.available 2018-11-30T23:41:31Z
dc.date.issued 2018
dc.identifier.uri https://hdl.handle.net/20.500.12866/4211
dc.description.abstract Background: Biosimilars could be a promising option to help decrease healthcare costs and expand access to treatment. There is no previous evidence of a global bibliometric analysis on biosimilars. Therefore, we aimed to assess the quantity and quality of worldwide biosimilars research. Methods: We performed a bibliometric analysis using documents about biosimilars published until December 2016 in journals indexed in Scopus. We extracted the annual research, languages, countries, journals, authors, institutions, citation frequency, and the metrics of journals. The data were quantitatively and qualitatively analyzed using Microsoft Excel 2013. Additional information about authors' participation was obtained using the R-package Bibliometrix. Publication activity was adjusted for the countries by population size. Also, author co-citation analysis and a term co-occurrence analysis with the terms included in the title and abstract of publications was presented as network visualization maps using VOSviewer. Results: A total of 2330 biosimilar-related documents identified in the Scopus database, most of them were articles (1452; 62.32%). The number of documents published had an exponential increased between 2004 and 2016 (p <0.001). The United States was the country with the highest production with 685 (29.40%) documents followed by Germany and UK with 293 (12.58%) and 248 (10.64%), respectively. Switzerland (11.05), Netherlands (5.85) and UK (3.83) showed the highest per capita ratio. The highest citation/article ratio were for the Netherlands (28.06), Spain (24.23), and France (20.11). Gabi Journal published 73 (3.13%) documents; both Biopharm International and Pharmaceutical Technology and Mabs, 41 (1.76%). Three out of top ten journals were Trade publications. Amgen Incorporated from the USA was the most prolific institution with 51 documents followed by Pfizer Inc. with 48. Terms about specific diseases and drugs were found in recent years, compared with terms such as legislation, structure, protein, dose and generic in the early years. Conclusions: Research production and publication of documents on biosimilars are increasing. The majority of publications came from high-income countries. The trends in terminology use are according to state of the art in the topic, and reflects the interest in the utilization of biosimilars in diseases who are expected to obtain benefits of its use. en_US
dc.language.iso eng
dc.publisher BioMed Central
dc.relation.ispartofseries Journal of Pharmaceutical Policy and Practice
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject United States en_US
dc.subject medical research en_US
dc.subject quantitative analysis en_US
dc.subject bibliometrics en_US
dc.subject Bibliometrics en_US
dc.subject Biomedical research (source: MeSH NLM) en_US
dc.subject biosimilar agent en_US
dc.subject Biosimilar pharmaceuticals en_US
dc.subject citation analysis en_US
dc.subject drug dose en_US
dc.subject drug structure en_US
dc.subject France en_US
dc.subject generic drug en_US
dc.subject Germany en_US
dc.subject law en_US
dc.subject medical literature en_US
dc.subject Netherlands en_US
dc.subject population size en_US
dc.subject protein en_US
dc.subject publication en_US
dc.subject publishing en_US
dc.subject qualitative analysis en_US
dc.subject Spain en_US
dc.subject Switzerland en_US
dc.subject United Kingdom en_US
dc.title A bibliometric analysis of the global research on biosimilars en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1186/s40545-018-0133-2
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.01.05
dc.relation.issn 2052-3211


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