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Clinicopathologic Features and Prognostic Impact of Lymph Node Involvement in Patients With Breast Implant-associated Anaplastic Large Cell Lymphoma

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dc.contributor.author Ferrufino-Schmidt, Maria C.
dc.contributor.author Medeiros, L. Jeffrey
dc.contributor.author Liu, Hui
dc.contributor.author Clemens, Mark W.
dc.contributor.author Hunt, Kelly K.
dc.contributor.author Laurent, Camille
dc.contributor.author Lofts, Julian
dc.contributor.author Amin, Mitual B.
dc.contributor.author Chai, Siaw Ming
dc.contributor.author Morine, Angela
dc.contributor.author Di Napoli, Arianna
dc.contributor.author Dogan, Ahmet
dc.contributor.author Parkash, Vinita
dc.contributor.author Bhagat, Govind
dc.contributor.author Tritz, Denise
dc.contributor.author Quesada, Andres E.
dc.contributor.author Pina-Oviedo, Sergio
dc.contributor.author Hu, Qinlong
dc.contributor.author Garcia-Gomez, Francisco J.
dc.contributor.author Borrero, Juan Jose
dc.contributor.author Horna, Pedro
dc.contributor.author Thakral, Beenu
dc.contributor.author Narbaitz, Marina
dc.contributor.author Hughes, R. Condon, III
dc.contributor.author Yang, Li-Jun
dc.contributor.author Fromm, Jonathan R.
dc.contributor.author Wu, David
dc.contributor.author Zhang, Da
dc.contributor.author Sohani, Aliyah R.
dc.contributor.author Hunt, John
dc.contributor.author Vadlamani, Indira U.
dc.contributor.author Morgan, Elizabeth A.
dc.contributor.author Ferry, Judith A.
dc.contributor.author Szigeti, Reka
dc.contributor.author Tardio, Juan C.
dc.contributor.author Granados, Rosario
dc.contributor.author Dertinger, Susanne
dc.contributor.author Offner, Felix A.
dc.contributor.author Pircher, Andreas
dc.contributor.author Hosry, Jeff
dc.contributor.author Young, Ken H.
dc.contributor.author Miranda, Roberto N.
dc.date.accessioned 2018-11-30T23:41:32Z
dc.date.available 2018-11-30T23:41:32Z
dc.date.issued 2018
dc.identifier.uri https://hdl.handle.net/20.500.12866/4225
dc.description.abstract Breast implant-associated anaplastic large cell lymphoma (BI-ALCL) is a rare T-cell lymphoma that arises around breast implants. Most patients manifest with periprosthetic effusion, whereas a subset of patients develops a tumor mass or lymph node involvement (LNI). The aim of this study is to describe the pathologic features of lymph nodes from patients with BI-ALCL and assess the prognostic impact of LNI. Clinical findings and histopathologic features of lymph nodes were assessed in 70 patients with BI-ALCL. LNI was defined by the histologic demonstration of ALCL in lymph nodes. Fourteen (20%) patients with BI-ALCL had LNI, all lymph nodes involved were regional, the most frequent were axillary (93%). The pattern of involvement was sinusoidal in 13 (92.9%) cases, often associated with perifollicular, interfollicular, and diffuse patterns. Two cases had Hodgkin-like patterns. The 5-year overall survival was 75% for patients with LNI and 97.9% for patients without LNI at presentation (P = 0.003). Six of 49 (12.2%) of patients with tumor confined by the capsule had LNI, compared with LNI in 8/21 (38%) patients with tumor beyond the capsule. Most patients with LNI achieved complete remission after various therapeutic approaches. Two of 14 (14.3%) patients with LNI died of disease compared with 0/56 (0%) patients without LNI. Twenty percent of patients with BI-ALCL had LNI by lymphoma, most often in a sinusoidal pattern. We conclude that BI-ALCL beyond capsule is associated with a higher risk of LNI. Involvement of lymph nodes was associated with decreased overall survival. Misdiagnosis as Hodgkin lymphoma is a pitfall. en_US
dc.language.iso eng
dc.publisher Wolters Kluwer Health
dc.relation.ispartofseries American Journal of Surgical Pathology
dc.rights info:eu-repo/semantics/restrictedAccess
dc.subject ALCL en_US
dc.subject anaplastic large cell lymphoma en_US
dc.subject breast implant en_US
dc.subject CD30 en_US
dc.subject Hodgkin lymphoma en_US
dc.subject lymph node involvement en_US
dc.subject T-cell lymphoma en_US
dc.title Clinicopathologic Features and Prognostic Impact of Lymph Node Involvement in Patients With Breast Implant-associated Anaplastic Large Cell Lymphoma en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1097/PAS.0000000000000985
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.01.09
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.11
dc.relation.issn 1532-0979


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