Clinicopathologic Features and Prognostic Impact of Lymph Node Involvement in Patients With Breast Implant-associated Anaplastic Large Cell Lymphoma

Chai, Siaw Ming; Narbaitz, Marina; Medeiros, L. Jeffrey; Tritz, Denise; Miranda, Roberto N.; Hu, Qinlong; Morine, Angela; Amin, Mitual B.; Granados, Rosario; Ferry, Judith A.; Thakral, Beenu; Hughes, R. Condon, III; Borrero, Juan Jose; Yang, Li-Jun; Hunt, Kelly K.; Pina-Oviedo, Sergio; Sohani, Aliyah R.; Parkash, Vinita; Morgan, Elizabeth A.; Liu, Hui; Clemens, Mark W.; Pircher, Andreas; Dertinger, Susanne; Quesada, Andres E.; Bhagat, Govind; Hunt, John; Di Napoli, Arianna; Wu, David; Zhang, Da; Vadlamani, Indira U.; Hosry, Jeff; Garcia-Gomez, Francisco J.; Fromm, Jonathan R.; Horna, Pedro; Tardio, Juan C.; Szigeti, Reka; Lofts, Julian; Dogan, Ahmet; Laurent, Camille; Offner, Felix A.; Ferrufino-Schmidt, Maria C.; Young, Ken H.

dc.contributor.author	Ferrufino-Schmidt, Maria C.
dc.contributor.author	Medeiros, L. Jeffrey
dc.contributor.author	Liu, Hui
dc.contributor.author	Clemens, Mark W.
dc.contributor.author	Hunt, Kelly K.
dc.contributor.author	Laurent, Camille
dc.contributor.author	Lofts, Julian
dc.contributor.author	Amin, Mitual B.
dc.contributor.author	Chai, Siaw Ming
dc.contributor.author	Morine, Angela
dc.contributor.author	Di Napoli, Arianna
dc.contributor.author	Dogan, Ahmet
dc.contributor.author	Parkash, Vinita
dc.contributor.author	Bhagat, Govind
dc.contributor.author	Tritz, Denise
dc.contributor.author	Quesada, Andres E.
dc.contributor.author	Pina-Oviedo, Sergio
dc.contributor.author	Hu, Qinlong
dc.contributor.author	Garcia-Gomez, Francisco J.
dc.contributor.author	Borrero, Juan Jose
dc.contributor.author	Horna, Pedro
dc.contributor.author	Thakral, Beenu
dc.contributor.author	Narbaitz, Marina
dc.contributor.author	Hughes, R. Condon, III
dc.contributor.author	Yang, Li-Jun
dc.contributor.author	Fromm, Jonathan R.
dc.contributor.author	Wu, David
dc.contributor.author	Zhang, Da
dc.contributor.author	Sohani, Aliyah R.
dc.contributor.author	Hunt, John
dc.contributor.author	Vadlamani, Indira U.
dc.contributor.author	Morgan, Elizabeth A.
dc.contributor.author	Ferry, Judith A.
dc.contributor.author	Szigeti, Reka
dc.contributor.author	Tardio, Juan C.
dc.contributor.author	Granados, Rosario
dc.contributor.author	Dertinger, Susanne
dc.contributor.author	Offner, Felix A.
dc.contributor.author	Pircher, Andreas
dc.contributor.author	Hosry, Jeff
dc.contributor.author	Young, Ken H.
dc.contributor.author	Miranda, Roberto N.
dc.date.accessioned	2018-11-30T23:41:32Z
dc.date.available	2018-11-30T23:41:32Z
dc.date.issued	2018
dc.identifier.uri	https://hdl.handle.net/20.500.12866/4225
dc.description.abstract	Breast implant-associated anaplastic large cell lymphoma (BI-ALCL) is a rare T-cell lymphoma that arises around breast implants. Most patients manifest with periprosthetic effusion, whereas a subset of patients develops a tumor mass or lymph node involvement (LNI). The aim of this study is to describe the pathologic features of lymph nodes from patients with BI-ALCL and assess the prognostic impact of LNI. Clinical findings and histopathologic features of lymph nodes were assessed in 70 patients with BI-ALCL. LNI was defined by the histologic demonstration of ALCL in lymph nodes. Fourteen (20%) patients with BI-ALCL had LNI, all lymph nodes involved were regional, the most frequent were axillary (93%). The pattern of involvement was sinusoidal in 13 (92.9%) cases, often associated with perifollicular, interfollicular, and diffuse patterns. Two cases had Hodgkin-like patterns. The 5-year overall survival was 75% for patients with LNI and 97.9% for patients without LNI at presentation (P = 0.003). Six of 49 (12.2%) of patients with tumor confined by the capsule had LNI, compared with LNI in 8/21 (38%) patients with tumor beyond the capsule. Most patients with LNI achieved complete remission after various therapeutic approaches. Two of 14 (14.3%) patients with LNI died of disease compared with 0/56 (0%) patients without LNI. Twenty percent of patients with BI-ALCL had LNI by lymphoma, most often in a sinusoidal pattern. We conclude that BI-ALCL beyond capsule is associated with a higher risk of LNI. Involvement of lymph nodes was associated with decreased overall survival. Misdiagnosis as Hodgkin lymphoma is a pitfall.	en_US
dc.language.iso	eng
dc.publisher	Wolters Kluwer Health
dc.relation.ispartofseries	American Journal of Surgical Pathology
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.subject	ALCL	en_US
dc.subject	anaplastic large cell lymphoma	en_US
dc.subject	breast implant	en_US
dc.subject	CD30	en_US
dc.subject	Hodgkin lymphoma	en_US
dc.subject	lymph node involvement	en_US
dc.subject	T-cell lymphoma	en_US
dc.title	Clinicopathologic Features and Prognostic Impact of Lymph Node Involvement in Patients With Breast Implant-associated Anaplastic Large Cell Lymphoma	en_US
dc.type	info:eu-repo/semantics/article
dc.identifier.doi	https://doi.org/10.1097/PAS.0000000000000985
dc.subject.ocde	https://purl.org/pe-repo/ocde/ford#3.01.09
dc.subject.ocde	https://purl.org/pe-repo/ocde/ford#3.02.11
dc.relation.issn	1532-0979