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Lichen planopilaris and frontal fibrosing alopecia cannot be differentiated by histopathology

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dc.contributor.author Galvez-Canseco, Aldo
dc.contributor.author Sperling, Leonard
dc.date.accessioned 2018-12-01T00:04:14Z
dc.date.available 2018-12-01T00:04:14Z
dc.date.issued 2018
dc.identifier.uri https://hdl.handle.net/20.500.12866/4242
dc.description.abstract Background: Lichen planopilaris (LPP) and frontal fibrosing alopecia (FFA) represent 2 entities that cause primary cicatricial alopecia. These entities are clinically different; nevertheless, the literature suggests that FFA represents a form of LPP. The main argument in support of this hypothesis is that previous studies comparing the histologic findings have not found obvious differences between these diseases. Methods: Our objective was to more critically compare and contrast 20 histologic findings of these diseases in a large number of patients in order to determine any significant histologic differences between LPP and FFA. Results: We found 3 parameters that were statistically different, namely the presence of terminal catagen-telogen hairs (50% FFA vs 23.5% LPP; P = .020); a severe perifollicular inflammatory infiltrate (29.4% LPP vs 4.6% FFA; P = .010) and a zone of concentric lamellar fibroplasia (85.3% LPP vs 63.6% FFA; P = .041). Conclusions: Although a few histologic features differ between FFA and LPP, we believe that these differences are too subtle or non-specific to distinguish between them with confidence. Therefore, clinical correlation is essential to establish the diagnosis. en_US
dc.language.iso eng
dc.publisher Wiley
dc.relation.ispartofseries Journal of Cutaneous Pathology
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject histopathology en_US
dc.subject Cicatricial alopecia en_US
dc.subject frontal fibrosing alopecia en_US
dc.subject lichen planopilaris en_US
dc.title Lichen planopilaris and frontal fibrosing alopecia cannot be differentiated by histopathology en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1111/cup.13112
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.01.09
dc.relation.issn 1600-0560


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