Universidad Peruana Cayetano Heredia
Lichen planopilaris and frontal fibrosing alopecia cannot be differentiated by histopathology
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| dc.contributor.author | Galvez-Canseco, Aldo | |
| dc.contributor.author | Sperling, Leonard | |
| dc.date.accessioned | 2018-12-01T00:04:14Z | |
| dc.date.available | 2018-12-01T00:04:14Z | |
| dc.date.issued | 2018 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12866/4242 | |
| dc.description.abstract | Background: Lichen planopilaris (LPP) and frontal fibrosing alopecia (FFA) represent 2 entities that cause primary cicatricial alopecia. These entities are clinically different; nevertheless, the literature suggests that FFA represents a form of LPP. The main argument in support of this hypothesis is that previous studies comparing the histologic findings have not found obvious differences between these diseases. Methods: Our objective was to more critically compare and contrast 20 histologic findings of these diseases in a large number of patients in order to determine any significant histologic differences between LPP and FFA. Results: We found 3 parameters that were statistically different, namely the presence of terminal catagen-telogen hairs (50% FFA vs 23.5% LPP; P = .020); a severe perifollicular inflammatory infiltrate (29.4% LPP vs 4.6% FFA; P = .010) and a zone of concentric lamellar fibroplasia (85.3% LPP vs 63.6% FFA; P = .041). Conclusions: Although a few histologic features differ between FFA and LPP, we believe that these differences are too subtle or non-specific to distinguish between them with confidence. Therefore, clinical correlation is essential to establish the diagnosis. | en_US |
| dc.language.iso | eng | |
| dc.publisher | Wiley | |
| dc.relation.ispartofseries | Journal of Cutaneous Pathology | |
| dc.rights | info:eu-repo/semantics/restrictedAccess | |
| dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es | |
| dc.subject | histopathology | en_US |
| dc.subject | Cicatricial alopecia | en_US |
| dc.subject | frontal fibrosing alopecia | en_US |
| dc.subject | lichen planopilaris | en_US |
| dc.title | Lichen planopilaris and frontal fibrosing alopecia cannot be differentiated by histopathology | en_US |
| dc.type | info:eu-repo/semantics/article | |
| dc.identifier.doi | https://doi.org/10.1111/cup.13112 | |
| dc.subject.ocde | https://purl.org/pe-repo/ocde/ford#3.01.09 | |
| dc.relation.issn | 1600-0560 |
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