Regulatory t-cell dynamics in cutaneous and mucocutaneous leishmaniasis due to leishmania braziliensis

Montes Delgado, Martin; Woll, Fernando; Vasquez, Nestor; White, A. Clinton; Llanos Cuentas, Elmer Alejandro; Barros, Nicolas; Valencia, B. M.; Sanchez, Cesar

dc.contributor.author	Barros, Nicolas
dc.contributor.author	Vasquez, Nestor
dc.contributor.author	Woll, Fernando
dc.contributor.author	Sanchez, Cesar
dc.contributor.author	Valencia, B. M.
dc.contributor.author	Llanos Cuentas, Elmer Alejandro
dc.contributor.author	White, A. Clinton
dc.contributor.author	Montes Delgado, Martin
dc.date.accessioned	2018-12-01T00:04:15Z
dc.date.available	2018-12-01T00:04:15Z
dc.date.issued	2018
dc.identifier.uri	https://hdl.handle.net/20.500.12866/4254
dc.description.abstract	To evaluate the dynamics of regulatory T cells (Tregs) during tegumentary leishmaniasis, we assessed peripheral blood and biopsies from 54 patients. Patients with cutaneous leishmaniasis (CL) had a decreased proportion of Tregs in the peripheral blood, but the proportion was higher in the biopsies of lesions. During treatment of CL, circulating Tregs increased reaching normal proportions, whereas antigen-specific interferon-γ responses diminished. By contrast, circulating Tregs from mucosal leishmaniasis patients failed to normalize during treatment. C-C chemokine receptor type 5 was expressed on a large proportion of Tregs at the site of infection. These results demonstrate increased Tregs at the site of infection, possibly homing from the peripheral circulation.	en_US
dc.language.iso	eng
dc.publisher	American Society of Tropical Medicine and Hygiene
dc.relation.ispartofseries	American Journal of Tropical Medicine and Hygiene (ASTMH Journal)
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.subject	adult	en_US
dc.subject	antigen specificity	en_US
dc.subject	antiparasitic therapy	en_US
dc.subject	Article	en_US
dc.subject	blood	en_US
dc.subject	chemical bond	en_US
dc.subject	chemokine receptor CCR5	en_US
dc.subject	controlled study	en_US
dc.subject	female	en_US
dc.subject	gamma interferon	en_US
dc.subject	human	en_US
dc.subject	human tissue	en_US
dc.subject	Leishmania braziliensis	en_US
dc.subject	major clinical study	en_US
dc.subject	male	en_US
dc.subject	molecular dynamics	en_US
dc.subject	mucocutaneous leishmaniasis	en_US
dc.subject	nonhuman	en_US
dc.subject	protein expression	en_US
dc.subject	regulatory T lymphocyte	en_US
dc.subject	skin biopsy	en_US
dc.subject	skin defect	en_US
dc.subject	skin leishmaniasis	en_US
dc.subject	stibogluconate sodium	en_US
dc.title	Regulatory t-cell dynamics in cutaneous and mucocutaneous leishmaniasis due to leishmania braziliensis	en_US
dc.type	info:eu-repo/semantics/article
dc.identifier.doi	https://doi.org/10.4269/ajtmh.17-0624
dc.subject.ocde	https://purl.org/pe-repo/ocde/ford#3.03.06
dc.relation.issn	1476-1645