The associations between psychotic experiences and substance use and substance use disorders: findings from the World Health Organization World Mental Health surveys

Karam, Elie G.; Sampson, Nancy A.; Makanjuola, Victor; Piazza Ferrand, Marina Julia; Karam, Georges; Kendler, Kenneth S.; Mneimneh, Zeina; Ten Have, Margreet; McGrath, John J.; Alonso, Jordi; Andrade, Laura H.; Florescu, Silvia; Bromet, Evelyn J.; Al-Hamzawi, Ali; Caldas-de-Almeida, Jose Miguel; Scott, Kate M.; Lee, Sing; Stagnaro, Juan Carlos; Medina-Mora, Maria E.; Lim, Carmen C. W.; Navarro-Mateu, Fernando; Lepine, Jean-Pierre; Kovess-Masfety, Viviane; Saha, Sukanta; Posada-Villa, Jose; Kessler, Ronald C.; Bruffaerts, Ronny; Aguilar-Gaxiola, Sergio; Haro, Josep M.; de Girolamo, Giovanni; Gureje, Oye; Degenhardt, Louisa

dc.contributor.author	Degenhardt, Louisa
dc.contributor.author	Saha, Sukanta
dc.contributor.author	Lim, Carmen C. W.
dc.contributor.author	Aguilar-Gaxiola, Sergio
dc.contributor.author	Al-Hamzawi, Ali
dc.contributor.author	Alonso, Jordi
dc.contributor.author	Andrade, Laura H.
dc.contributor.author	Bromet, Evelyn J.
dc.contributor.author	Bruffaerts, Ronny
dc.contributor.author	Caldas-de-Almeida, Jose Miguel
dc.contributor.author	de Girolamo, Giovanni
dc.contributor.author	Florescu, Silvia
dc.contributor.author	Gureje, Oye
dc.contributor.author	Haro, Josep M.
dc.contributor.author	Karam, Elie G.
dc.contributor.author	Karam, Georges
dc.contributor.author	Kovess-Masfety, Viviane
dc.contributor.author	Lee, Sing
dc.contributor.author	Lepine, Jean-Pierre
dc.contributor.author	Makanjuola, Victor
dc.contributor.author	Medina-Mora, Maria E.
dc.contributor.author	Mneimneh, Zeina
dc.contributor.author	Navarro-Mateu, Fernando
dc.contributor.author	Piazza Ferrand, Marina Julia
dc.contributor.author	Posada-Villa, Jose
dc.contributor.author	Sampson, Nancy A.
dc.contributor.author	Scott, Kate M.
dc.contributor.author	Stagnaro, Juan Carlos
dc.contributor.author	Ten Have, Margreet
dc.contributor.author	Kendler, Kenneth S.
dc.contributor.author	Kessler, Ronald C.
dc.contributor.author	McGrath, John J.
dc.date.accessioned	2018-12-03T17:02:45Z
dc.date.available	2018-12-03T17:02:45Z
dc.date.issued	2018
dc.identifier.uri	https://hdl.handle.net/20.500.12866/4279
dc.description.abstract	Background and aims: Prior research has found bidirectional associations between psychotic experiences (PEs) and selected substance use disorders. We aimed to extend this research by examining the bidirectional association between PEs and various types of substance use (SU) and substance use disorders (SUDs), and the influence of antecedent mental disorders on these associations. Design, setting, participants and measurements: We used data from the World Health Organization World Mental Health surveys. A total of 30902 adult respondents across 18 countries were assessed for (a) six types of life-time PEs, (b) a range of types of SU and DSM-IV SUDs and (c) mental disorders using the Composite International Diagnostic Interview. Discrete-time survival analyses based on retrospective age-at-onset reports examined the bidirectional associations between PEs and SU/SUDs controlling for antecedent mental disorders. Findings: After adjusting for demographics, comorbid SU/SUDs and antecedent mental disorders, those with prior alcohol use disorders [odds ratio (OR)=1.6, 95% confidence interval (CI)=1.2-2.0], extra-medical prescription drug use (OR=1.5, 95% CI=1.1-1.9), alcohol use (OR=1.4, 95% CI=1.1-1.7) and tobacco use (OR=1.3, 95% CI=1.0-1.8) had increased odds of subsequent first onset of PEs. In contrast, those with temporally prior PEs had increased odds of subsequent onset of tobacco use (OR=1.5, 95% CI=1.2-1.9), alcohol use (OR=1.3, 95% CI=1.1-1.6) or cannabis use (OR=1.3, 95% CI=1.0-1.5) as well as of all substance use disorders (ORs ranged between 1.4 and 1.5). There was a dose response relationship between both count and frequency of PEs and increased subsequent odds of selected SU/SUDs. Conclusions: Associations between psychotic experiences (PEs) and substance use/substance use disorders (SU/SUDs) are often bidirectional, but not all types of SU/SUDs are associated with PEs. These findings suggest that it is important to be aware of the presence of PEs within those with SUDs or at risk of SUDs, given the plausibility that they may each impact upon the other.	en_US
dc.description.sponsorship	Este trabajo fue financiado en el marco del Peruvian World Mental Health Study por el Instituto Nacional de Salud del Ministerio de Salud del Perú.	es_PE
dc.language.iso	eng
dc.publisher	Wiley
dc.relation.ispartofseries	Addiction
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.subject	substance use	en_US
dc.subject	cannabis	en_US
dc.subject	Alcohol	en_US
dc.subject	mental disorder	en_US
dc.subject	nicotine	en_US
dc.subject	prescription drug	en_US
dc.subject	psychotic experiences	en_US
dc.subject	substance abuse disorder	en_US
dc.subject	substance dependence disorder	en_US
dc.subject	tobacco	en_US
dc.title	The associations between psychotic experiences and substance use and substance use disorders: findings from the World Health Organization World Mental Health surveys	en_US
dc.type	info:eu-repo/semantics/article
dc.identifier.doi	https://doi.org/10.1111/add.14145
dc.subject.ocde	https://purl.org/pe-repo/ocde/ford#3.02.24
dc.subject.ocde	https://purl.org/pe-repo/ocde/ford#3.02.25
dc.type.version	info:eu-repo/semantics/publishedVersion
dc.relation.issn	1360-0443