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Rationale and design for the detection and neurological impact of cerebrovascular events in non-cardiac surgery patients cohort evaluation (NeuroVISION) study: a prospective international cohort study

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dc.contributor.author Mrkobrada, Marko
dc.contributor.author Chan, Matthew T. V.
dc.contributor.author Cowan, David
dc.contributor.author Spence, Jessica
dc.contributor.author Campbell, Douglas
dc.contributor.author Wang, Chew Yin
dc.contributor.author Torres, David
dc.contributor.author Malaga, German
dc.contributor.author Sanders, Robert D.
dc.contributor.author Brown, Carl
dc.contributor.author Sigamani, Alben
dc.contributor.author Szczeklik, Wojciech
dc.contributor.author Dmytriw, Adam Andrew
dc.contributor.author Agid, Ronit
dc.contributor.author Smith, Eric E.
dc.contributor.author Hill, Michael D.
dc.contributor.author Sharma, Manas
dc.contributor.author Sharma, Mukul
dc.contributor.author Tsai, Scott
dc.contributor.author Mensinkai, Arun
dc.contributor.author Sahlas, Demetrios J.
dc.contributor.author Guyatt, Gordon
dc.contributor.author Pettit, Shirley
dc.contributor.author Copland, Ingrid
dc.contributor.author Wu, William K. K.
dc.contributor.author Yu, Simon C. H.
dc.contributor.author Gin, Tony
dc.contributor.author Loh, Pui San
dc.contributor.author Ramli, Norlisah
dc.contributor.author Siow, Yee Lein
dc.contributor.author Short, Timothy G.
dc.contributor.author Waymouth, Ellen
dc.contributor.author Kumar, Jonathan
dc.contributor.author Dasgupta, Monidipa
dc.contributor.author Murkin, John M.
dc.contributor.author Fuentes, Maite
dc.contributor.author Ortiz-Soriano, Victor
dc.contributor.author Lindroth, Heidi
dc.contributor.author Simpson, Sara
dc.contributor.author Sessler, Daniel
dc.contributor.author Devereaux, P. J.
dc.date.accessioned 2018-12-03T17:02:49Z
dc.date.available 2018-12-03T17:02:49Z
dc.date.issued 2018
dc.identifier.uri https://hdl.handle.net/20.500.12866/4299
dc.description.abstract OBJECTIVES: Covert stroke after non-cardiac surgery may have substantial impact on duration and quality of life. In non-surgical patients, covert stroke is more common than overt stroke and is associated with an increased risk of cognitive decline and dementia. Little is known about covert stroke after non-cardiac surgery.NeuroVISION is a multicentre, international, prospective cohort study that will characterise the association between perioperative acute covert stroke and postoperative cognitive function. SETTING AND PARTICIPANTS: We are recruiting study participants from 12 tertiary care hospitals in 10 countries on 5 continents. PARTICIPANTS: We are enrolling patients ≥65 years of age, requiring hospital admission after non-cardiac surgery, who have an anticipated length of hospital stay of at least 2 days after elective non-cardiac surgery that occurs under general or neuraxial anaesthesia. PRIMARY AND SECONDARY OUTCOME MEASURES: Patients are recruited before elective non-cardiac surgery, and their cognitive function is measured using the Montreal Cognitive Assessment (MoCA) instrument. After surgery, a brain MRI study is performed between postoperative days 2 and 9 to determine the presence of acute brain infarction. One year after surgery, the MoCA is used to assess postoperative cognitive function. Physicians and patients are blinded to the MRI study results until after the last patient follow-up visit to reduce outcome ascertainment bias.We will undertake a multivariable logistic regression analysis in which the dependent variable is the change in cognitive function 1 year after surgery, and the independent variables are acute perioperative covert stroke as well as other clinical variables that are associated with cognitive dysfunction. CONCLUSIONS: The NeuroVISION study will characterise the epidemiology of covert stroke and its clinical consequences. This will be the largest and the most comprehensive study of perioperative stroke after non-cardiac surgery. en_US
dc.language.iso eng
dc.publisher BMJ Publishing Group
dc.relation.ispartof urn:issn:2044-6055
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject adult anaesthesia en_US
dc.subject adult surgery en_US
dc.subject stroke medicine en_US
dc.title Rationale and design for the detection and neurological impact of cerebrovascular events in non-cardiac surgery patients cohort evaluation (NeuroVISION) study: a prospective international cohort study en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1136/bmjopen-2018-023391


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