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A Mycoses Study Group International Prospective Study of Phaeohyphomycosis: An Analysis of 99 Proven/Probable Cases

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dc.contributor.author Revankar, Sanjay G.
dc.contributor.author Baddley, John W.
dc.contributor.author Chen, Sharon C.-A.
dc.contributor.author Kauffman, Carol A.
dc.contributor.author Slavin, Monica
dc.contributor.author Vazquez, Jose A.
dc.contributor.author Seas, Carlos
dc.contributor.author Morris, Michele I.
dc.contributor.author Nguyen, M. Hong
dc.contributor.author Shoham, Shmuel
dc.contributor.author Thompson, George R.
dc.contributor.author Alexander, Barbara D.
dc.contributor.author Simkins, Jacques
dc.contributor.author Ostrosky-Zeichner, Luis
dc.contributor.author Mullane, Kathleen
dc.contributor.author Alangaden, George
dc.contributor.author Andes, David R.
dc.contributor.author Cornely, Oliver A.
dc.contributor.author Wahlers, Kerstin
dc.contributor.author Lockhart, Shawn R.
dc.contributor.author Pappas, Peter G.
dc.date.accessioned 2019-01-25T15:02:14Z
dc.date.available 2019-01-25T15:02:14Z
dc.date.issued 2017
dc.identifier.uri https://hdl.handle.net/20.500.12866/4587
dc.description.abstract Background: Phaeohyphomycosis is infection caused by dematiaceous, or darkly pigmented, fungi. The spectrum of disease is broad, and optimal therapy remains poorly defined. The Mycoses Study Group established an international case registry of patients with proven/probable phaeohyphomycosis with the goal of improving the recognition and management of these infections. Methods: Patients from 18 sites in 3 countries were enrolled from 2009-2015. Cases were categorized as local superficial, local deep (pulmonary, sinus, osteoarticular infections), and disseminated infections. End points were clinical response (partial and complete) and all-cause mortality at 30 days and end of follow-up. Results: Of 99 patients, 32 had local superficial infection, 41 had local deep infection, and 26 had disseminated infection. The most common risk factors were corticosteroids, solid organ transplantation, malignancy, and diabetes. Cultures were positive in 98% of cases. All-cause mortality was 16% at 30 days and 33% at end of follow-up, and 18 of 26 (69%) with dissemination died. Itraconazole was most commonly used for local infections, and voriconazole was used for more severe infections, often in combination with terbinafine or amphotericin B. Conclusions: Phaeohyphomycosis is an increasingly recognized infection. Culture remains the most frequently used diagnostic method. Triazoles are currently the drugs of choice, often combined with other agents. Further studies are needed to develop optimal therapies for disseminated infections. en_US
dc.language.iso eng
dc.publisher Oxford University Press
dc.relation.ispartof urn:issn:2328-8957
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject dematiaceous fungus en_US
dc.subject itraconazole en_US
dc.subject phaeohyphomycosis en_US
dc.subject voriconazole en_US
dc.title A Mycoses Study Group International Prospective Study of Phaeohyphomycosis: An Analysis of 99 Proven/Probable Cases en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1093/ofid/ofx200

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