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A new phthalide derivative from Peperomia nivalis

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dc.contributor.author Vasquez-Ocmin, Pedro
dc.contributor.author Haddad, Mohamed
dc.contributor.author Gadea, Alice
dc.contributor.author Jullian, Valerie
dc.contributor.author Castillo Pareja, Denis Helan
dc.contributor.author Paloque, Lucie
dc.contributor.author Cerapio, Juan Pablo
dc.contributor.author Bourdy, Genevieve
dc.contributor.author Sauvain, Michel Henri Auguste
dc.date.accessioned 2019-01-25T15:02:14Z
dc.date.available 2019-01-25T15:02:14Z
dc.date.issued 2016
dc.identifier.uri https://hdl.handle.net/20.500.12866/4588
dc.description.abstract One new phthalide (1) was isolated from aerial parts of Peperomia nivalis, along with known compounds (2 and 3), reported in this species for the first time. The structure of the new compound was characterised on the basis of 1D ((1)H and (13)C NMR), 2D (COSY, HMQC, HMBC and NOESY) NMR and high-resolution mass spectral (HRMS) data. Compound 2 was isolated from a natural source for the first time but previously synthesised. Compounds 1-3 were evaluated for their anti-Helicobacter pylori and anti-Plasmodium falciparum activities. Compound 1 showed moderate activities against H. pylori (MIC 47.5 muM) and the F32-Tanzania strain of P. falciparum (IC50 8.5 muM). Compounds 2 and 3 exhibited weak anti-H. pylori activity (MIC 241.3 and 237.6 muM, respectively) and were inactive against P. falciparum. en_US
dc.language.iso eng
dc.publisher Taylor and Francis
dc.relation.ispartofseries Natural Product Research
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Peru en_US
dc.subject Animals en_US
dc.subject Microbial Sensitivity Tests en_US
dc.subject Magnetic Resonance Spectroscopy en_US
dc.subject Spectrophotometry, Ultraviolet en_US
dc.subject Helicobacter pylori en_US
dc.subject NMR en_US
dc.subject Peperomia nivalis en_US
dc.subject phthalide en_US
dc.subject Plasmodium en_US
dc.subject secondary metabolites en_US
dc.subject Anti-Bacterial Agents/chemistry/pharmacology en_US
dc.subject Antimalarials/chemistry/pharmacology en_US
dc.subject Benzofurans/chemistry/pharmacology en_US
dc.subject Helicobacter pylori/drug effects en_US
dc.subject Peperomia/chemistry en_US
dc.subject Plasmodium falciparum/drug effects en_US
dc.title A new phthalide derivative from Peperomia nivalis en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1080/14786419.2016.1219857
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#1.06.10
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#1.06.03
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#1.04.07
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#1.04.01
dc.relation.issn 1478-6427


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