A new phthalide derivative from Peperomia nivalis

Jullian, Valerie; Cerapio, Juan Pablo; Vasquez-Ocmin, Pedro; Gadea, Alice; Haddad, Mohamed; Bourdy, Genevieve; Castillo Pareja, Denis Helan; Sauvain, Michel Henri Auguste; Paloque, Lucie

dc.contributor.author	Vasquez-Ocmin, Pedro
dc.contributor.author	Haddad, Mohamed
dc.contributor.author	Gadea, Alice
dc.contributor.author	Jullian, Valerie
dc.contributor.author	Castillo Pareja, Denis Helan
dc.contributor.author	Paloque, Lucie
dc.contributor.author	Cerapio, Juan Pablo
dc.contributor.author	Bourdy, Genevieve
dc.contributor.author	Sauvain, Michel Henri Auguste
dc.date.accessioned	2019-01-25T15:02:14Z
dc.date.available	2019-01-25T15:02:14Z
dc.date.issued	2016
dc.identifier.uri	https://hdl.handle.net/20.500.12866/4588
dc.description.abstract	One new phthalide (1) was isolated from aerial parts of Peperomia nivalis, along with known compounds (2 and 3), reported in this species for the first time. The structure of the new compound was characterised on the basis of 1D ((1)H and (13)C NMR), 2D (COSY, HMQC, HMBC and NOESY) NMR and high-resolution mass spectral (HRMS) data. Compound 2 was isolated from a natural source for the first time but previously synthesised. Compounds 1-3 were evaluated for their anti-Helicobacter pylori and anti-Plasmodium falciparum activities. Compound 1 showed moderate activities against H. pylori (MIC 47.5 muM) and the F32-Tanzania strain of P. falciparum (IC50 8.5 muM). Compounds 2 and 3 exhibited weak anti-H. pylori activity (MIC 241.3 and 237.6 muM, respectively) and were inactive against P. falciparum.	en_US
dc.language.iso	eng
dc.publisher	Taylor and Francis
dc.relation.ispartofseries	Natural Product Research
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.rights.uri	https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject	Peru	en_US
dc.subject	Animals	en_US
dc.subject	Microbial Sensitivity Tests	en_US
dc.subject	Magnetic Resonance Spectroscopy	en_US
dc.subject	Spectrophotometry, Ultraviolet	en_US
dc.subject	Helicobacter pylori	en_US
dc.subject	NMR	en_US
dc.subject	Peperomia nivalis	en_US
dc.subject	phthalide	en_US
dc.subject	Plasmodium	en_US
dc.subject	secondary metabolites	en_US
dc.subject	Anti-Bacterial Agents/chemistry/pharmacology	en_US
dc.subject	Antimalarials/chemistry/pharmacology	en_US
dc.subject	Benzofurans/chemistry/pharmacology	en_US
dc.subject	Helicobacter pylori/drug effects	en_US
dc.subject	Peperomia/chemistry	en_US
dc.subject	Plasmodium falciparum/drug effects	en_US
dc.title	A new phthalide derivative from Peperomia nivalis	en_US
dc.type	info:eu-repo/semantics/article
dc.identifier.doi	https://doi.org/10.1080/14786419.2016.1219857
dc.subject.ocde	https://purl.org/pe-repo/ocde/ford#1.06.10
dc.subject.ocde	https://purl.org/pe-repo/ocde/ford#1.06.03
dc.subject.ocde	https://purl.org/pe-repo/ocde/ford#1.04.07
dc.subject.ocde	https://purl.org/pe-repo/ocde/ford#1.04.01
dc.relation.issn	1478-6427