Universidad Peruana Cayetano Heredia

A Prospective Cohort Multicenter Study of Molecular Epidemiology and Phylogenomics of Staphylococcus aureus Bacteremia in Nine Latin American Countries

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dc.contributor.author Arias, Cesar A.
dc.contributor.author Reyes, Jinnethe
dc.contributor.author Carvajal, Lina Paola
dc.contributor.author Rincon, Sandra
dc.contributor.author Diaz, Lorena
dc.contributor.author Panesso, Diana
dc.contributor.author Ibarra, Gabriel
dc.contributor.author Rios, Rafael
dc.contributor.author Munita, Jose M.
dc.contributor.author Salles, Mauro J.
dc.contributor.author Alvarez-Moreno, Carlos
dc.contributor.author Labarca, Jaime
dc.contributor.author García Apac, Coralith Marlinda
dc.contributor.author Luna, Carlos M.
dc.contributor.author Mejia-Villatoro, Carlos
dc.contributor.author Zurita, Jeannete
dc.contributor.author Guzman-Blanco, Manuel
dc.contributor.author Rodriguez-Noriega, Eduardo
dc.contributor.author Narechania, Apurva
dc.contributor.author Rojas, Laura J.
dc.contributor.author Planet, Paul J.
dc.contributor.author Weinstock, George M.
dc.contributor.author Gotuzzo Herencia, José Eduardo
dc.contributor.author Seas Ramos, Carlos Rafael
dc.date.accessioned 2019-01-25T15:02:14Z
dc.date.available 2019-01-25T15:02:14Z
dc.date.issued 2017
dc.identifier.uri https://hdl.handle.net/20.500.12866/4589
dc.description.abstract Staphylococcus aureus is an important pathogen causing a spectrum of diseases ranging from mild skin and soft tissue infections to life-threatening conditions. Bloodstream infections are particularly important, and the treatment approach is complicated by the presence of methicillin-resistant S. aureus (MRSA) isolates. The emergence of new genetic lineages of MRSA has occurred in Latin America (LA) with the rise and dissemination of the community-associated USA300 Latin American variant (USA300-LV). Here, we prospectively characterized bloodstream MRSA recovered from selected hospitals in 9 Latin American countries. All isolates were typed by pulsed-field gel electrophoresis (PFGE) and subjected to antibiotic susceptibility testing. Whole-genome sequencing was performed on 96 MRSA representatives. MRSA represented 45% of all (1,185 S. aureus) isolates. The majority of MRSA isolates belonged to clonal cluster (CC) 5. In Colombia and Ecuador, most isolates (≥72%) belonged to the USA300-LV lineage (CC8). Phylogenetic reconstructions indicated that MRSA isolates from participating hospitals belonged to three major clades. Clade A grouped isolates with sequence type 5 (ST5), ST105, and ST1011 (mostly staphylococcal chromosomal cassette mec [SCCmec] I and II). Clade B included ST8, ST88, ST97, and ST72 strains (SCCmec IV, subtypes a, b, and c/E), and clade C grouped mostly Argentinian MRSA belonging to ST30. In summary, CC5 MRSA was prevalent in bloodstream infections in LA with the exception of Colombia and Ecuador, where USA300-LV is now the dominant lineage. Clonal replacement appears to be a common phenomenon, and continuous surveillance is crucial to identify changes in the molecular epidemiology of MRSA. en_US
dc.language.iso eng
dc.publisher American Society for Microbiology
dc.relation.ispartofseries Antimicrobial Agents and Chemotherapy
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject bacteremia en_US
dc.subject Latin America en_US
dc.subject Staphylococcus aureus en_US
dc.subject Anti-Bacterial Agents/pharmacology en_US
dc.subject Bacteremia/epidemiology/microbiology en_US
dc.subject Genome, Bacterial/genetics en_US
dc.subject Humans en_US
dc.subject Latin America en_US
dc.subject Methicillin-Resistant Staphylococcus aureus/classification/drug effects/genetics/isolation & purification en_US
dc.subject Microbial Sensitivity Tests en_US
dc.subject Molecular Epidemiology en_US
dc.subject Multilocus Sequence Typing en_US
dc.subject Prospective Studies en_US
dc.subject Staphylococcal Infections/epidemiology/microbiology en_US
dc.title A Prospective Cohort Multicenter Study of Molecular Epidemiology and Phylogenomics of Staphylococcus aureus Bacteremia in Nine Latin American Countries en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1128/AAC.00816-17
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.08
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.01.05
dc.relation.issn 1098-6596


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