Universidad Peruana Cayetano Heredia
Association Between Plasma N-Acylethanolamides and High Hemoglobin Concentration in Southern Peruvian Highlanders
JavaScript is disabled for your browser. Some features of this site may not work without it.
Mostrar el registro sencillo del ítem
| dc.contributor.author | Alarcón Yaquetto, Dulce Esperanza | |
| dc.contributor.author | Caballero, Lidia | |
| dc.contributor.author | Gonzales Rengifo, Gustavo Francisco | |
| dc.date.accessioned | 2019-01-25T15:02:19Z | |
| dc.date.available | 2019-01-25T15:02:19Z | |
| dc.date.issued | 2017 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12866/4608 | |
| dc.description.abstract | High-altitude (HA) hypoxia is a stressful condition endured by organisms through different mechanisms. Failing to adapt to chronic HA exposure leads to a disease called chronic mountain sickness (CMS) characterized by excessive erythrocytosis (hemoglobin [Hb] ≥19 g/dL for women and ≥21 g/dL for men). Genes encoding for peroxisome proliferator-activated receptor (PPAR) subunits α and γ have been proposed as candidate genes for HA adaptation. N-acylethanolamides (NAEs) are endogenous fatty acid substances that bind to PPAR-α and -γ. NAEs are also able to modulate the endocannabinoid system, a signaling pathway activated in physiological stressful conditions. In the frame of a metabolomic study, we measured plasma levels of four NAEs: palmitoylethanolamide (PEA), oleoylethanolamide (OEA), stearoyl ethanolamide (SEA), and linoleoyl ethanolamide (LEA) in natives from Puno (3830 m), a city located in the Peruvian Southern Andes, and Lima (150 m). All NAEs were significantly higher in the HA population (p < 0.001, q < 0.001). Subjects with higher NAE values were those with higher Hb concentration and lower pulse oxygen saturation. However, there was no association between NAEs and CMS score. Our results suggest that PEA and OEA could be involved in physiological regulation following long-term HA exposure. | en_US |
| dc.description.sponsorship | Este trabajo fue financiado por CONCYTEC/CIENCIACTIVA [número de contrato 010-2014]. | es_PE |
| dc.language.iso | eng | |
| dc.publisher | Mary Ann Liebert | |
| dc.relation.ispartofseries | High Altitude Medicine and Biology | |
| dc.rights | info:eu-repo/semantics/restrictedAccess | |
| dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es | |
| dc.subject | chronic mountain sickness | en_US |
| dc.subject | hemoglobin | en_US |
| dc.subject | high altitude | en_US |
| dc.subject | hypoxemia | en_US |
| dc.subject | N-acylethanolamides | en_US |
| dc.title | Association Between Plasma N-Acylethanolamides and High Hemoglobin Concentration in Southern Peruvian Highlanders | en_US |
| dc.type | info:eu-repo/semantics/article | |
| dc.identifier.doi | https://doi.org/10.1089/ham.2016.0148 | |
| dc.subject.ocde | https://purl.org/pe-repo/ocde/ford#3.01.08 | |
| dc.subject.ocde | https://purl.org/pe-repo/ocde/ford#3.03.11 | |
| dc.subject.ocde | https://purl.org/pe-repo/ocde/ford#3.03.05 | |
| dc.relation.issn | 1557-8682 |
Ficheros en el ítem
| Ficheros | Tamaño | Formato | Ver |
|---|---|---|---|
|
No hay ficheros asociados a este ítem. |
|||
Este ítem aparece en la(s) siguiente(s) colección(ones)
-
Artículos en revistas indizadas [4988]
Recuperados de bases de datos bibliográficas
Excepto si se señala otra cosa, la licencia del ítem se describe como info:eu-repo/semantics/restrictedAccess
