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Association between sleep difficulties as well as duration and hypertension: is BMI a mediator?

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dc.contributor.author Carrillo-Larco, R. M.
dc.contributor.author Bernabe-Ortiz, A.
dc.contributor.author Sacksteder, K. A.
dc.contributor.author Diez-Canseco, F.
dc.contributor.author Cárdenas, M. K.
dc.contributor.author Gilman, R. H.
dc.contributor.author Miranda, J. J.
dc.date.accessioned 2019-01-25T15:02:19Z
dc.date.available 2019-01-25T15:02:19Z
dc.date.issued 2017
dc.identifier.uri https://hdl.handle.net/20.500.12866/4609
dc.description.abstract Sleep difficulties and short sleep duration have been associated with hypertension. Though body mass index (BMI) may be a mediator variable, the mediation effect has not been defined. We aimed to assess the association between sleep duration and sleep difficulties with hypertension, to determine if BMI is a mediator variable, and to quantify the mediation effect. We conducted a mediation analysis and calculated prevalence ratios with 95% confidence intervals. The exposure variables were sleep duration and sleep difficulties, and the outcome was hypertension. Sleep difficulties were statistically significantly associated with a 43% higher prevalence of hypertension in multivariable analyses; results were not statistically significant for sleep duration. In these analyses, and in sex-specific subgroup analyses, we found no strong evidence that BMI mediated the association between sleep indices and risk of hypertension. Our findings suggest that BMI does not appear to mediate the association between sleep patterns and hypertension. These results highlight the need to further study the mechanisms underlying the relationship between sleep patterns and cardiovascular risk factors. en_US
dc.language.iso eng
dc.publisher Cambridge University Press
dc.relation.ispartof urn:issn:2054-4200
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Body mass index en_US
dc.subject hypertension en_US
dc.subject obesity en_US
dc.subject sleep apnea en_US
dc.subject sleep disorders en_US
dc.title Association between sleep difficulties as well as duration and hypertension: is BMI a mediator? en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1017/gheg.2017.10
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.00 es_PE
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.09
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.05


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