Universidad Peruana Cayetano Heredia

Defining the next generation of Plasmodium vivax diagnostic tests for control and elimination: Target product profiles

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dc.contributor.author Ding, Xavier C.
dc.contributor.author Ade, Maria Paz
dc.contributor.author Baird, J. Kevin
dc.contributor.author Cheng, Qin
dc.contributor.author Cunningham, Jane
dc.contributor.author Dhorda, Mehul
dc.contributor.author Drakeley, Chris
dc.contributor.author Felger, Ingrid
dc.contributor.author Gamboa Vilela, Dionicia Baziliza
dc.contributor.author Harbers, Matthias
dc.contributor.author Herrera, Socrates
dc.contributor.author Lucchi, Naomi
dc.contributor.author Mayor, Alfredo
dc.contributor.author Mueller, Ivo
dc.contributor.author Sattabongkot, Jetsumon
dc.contributor.author Ratsimbason, Arsene
dc.contributor.author Richards, Jack
dc.contributor.author Tanner, Marcel
dc.contributor.author Gonzalez, Iveth J.
dc.date.accessioned 2019-01-25T15:02:22Z
dc.date.available 2019-01-25T15:02:22Z
dc.date.issued 2017
dc.identifier.uri https://hdl.handle.net/20.500.12866/4629
dc.description.abstract The global prevalence of malaria has decreased over the past fifteen years, but similar gains have not been realized against Plasmodium vivax because this species is less responsive to conventional malaria control interventions aimed principally at P. falciparum. Approximately half of all malaria cases outside of Africa are caused by P. vivax. This species places dormant forms in human liver that cause repeated clinical attacks without involving another mosquito bite. The diagnosis of acute patent P. vivax malaria relies primarily on light microscopy. Specific rapid diagnostic tests exist but typically perform relatively poorly compared to those for P. falciparum. Better diagnostic tests are needed for P. vivax. To guide their development, FIND, in collaboration with P. vivax experts, identified the specific diagnostic needs associated with this species and defined a series of three distinct target product profiles, each aimed at a particular diagnostic application: (i) point-of-care of acutely ill patients for clinical care purposes; (ii) point-of-care asymptomatic and otherwise sub-patent residents for public health purposes, e.g., mass screen and treat campaigns; and (iii) ultra-sensitive not point-of-care diagnosis for epidemiological research/surveillance purposes. This report presents and discusses the rationale for these P. vivax-specific diagnostic target product profiles. These contribute to the rational development of fit-for-purpose diagnostic tests suitable for the clinical management, control and elimination of P. vivax malaria. en_US
dc.language.iso eng
dc.publisher Public Library of Science
dc.relation.ispartofseries PLoS Neglected Tropical Diseases
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Humans en_US
dc.subject Species Specificity en_US
dc.subject Diagnostic Tests, Routine en_US
dc.subject Point-of-Care Systems en_US
dc.subject Malaria, Falciparum/diagnosis/parasitology/prevention & control en_US
dc.subject Malaria, Vivax/diagnosis/parasitology/prevention & control en_US
dc.subject Plasmodium falciparum/isolation & purification en_US
dc.subject Plasmodium vivax/isolation & purification en_US
dc.title Defining the next generation of Plasmodium vivax diagnostic tests for control and elimination: Target product profiles en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1371/journal.pntd.0005516
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.06
dc.relation.issn 1935-2735


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