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Evolutionary structure of Plasmodium falciparum major variant surface antigen genes in South America: Implications for epidemic transmission and surveillance

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dc.contributor.author Rougeron, Virginie
dc.contributor.author Tiedje, Kathryn E.
dc.contributor.author Chen, Donald S.
dc.contributor.author Rask, Thomas S.
dc.contributor.author Gamboa, Dionicia
dc.contributor.author Maestre, Amanda
dc.contributor.author Musset, Lise
dc.contributor.author Legrand, Eric
dc.contributor.author Noya, Oscar
dc.contributor.author Yalcindag, Erhan
dc.contributor.author Renaud, François
dc.contributor.author Prugnolle, Franck
dc.contributor.author Day, Karen P.
dc.date.accessioned 2019-01-25T15:18:34Z
dc.date.available 2019-01-25T15:18:34Z
dc.date.issued 2017
dc.identifier.uri https://hdl.handle.net/20.500.12866/4649
dc.description.abstract Strong founder effects resulting from human migration out of Africa have led to geographic variation in single nucleotide polymorphisms (SNPs) and microsatellites (MS) of the malaria parasite, Plasmodium falciparum. This is particularly striking in South America where two major founder populations of P. falciparum have been identified that are presumed to have arisen from the transatlantic slave trade. Given the importance of the major variant surface antigen of the blood stages of P. falciparum as both a virulence factor and target of immunity, we decided to investigate the population genetics of the genes encoding "Plasmodium falciparum Erythrocyte Membrane Protein 1" (Pf EMP1) among several countries in South America, in order to evaluate the transmission patterns of malaria in this continent. Deep sequencing of the DBLα domain of var genes from 128 P. falciparum isolates from five locations in South America was completed using a 454 high throughput sequencing protocol. Striking geographic variation in var DBLα sequences, similar to that seen for SNPs and MS markers, was observed. Colombia and French Guiana had distinct var DBLα sequences, whereas Peru and Venezuela showed an admixture. The importance of such geographic variation to herd immunity and malaria vaccination is discussed. en_US
dc.language.iso eng
dc.publisher Wiley
dc.relation.ispartof urn:issn:2045-7758
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject evolutionary structure en_US
dc.subject Plasmodium falciparum en_US
dc.subject Plasmodium falciparum Erythrocyte Membrane Protein 1 en_US
dc.subject population genomics en_US
dc.subject var genes en_US
dc.title Evolutionary structure of Plasmodium falciparum major variant surface antigen genes in South America: Implications for epidemic transmission and surveillance en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1002/ece3.3425
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.00 es_PE
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#1.06.15
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#1.06.13

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