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High prevalence of very-low Plasmodium falciparum and Plasmodium vivax parasitaemia carriers in the Peruvian Amazon: insights into local and occupational mobility-related transmission

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dc.contributor.author Carrasco Escobar, Gabriel
dc.contributor.author Miranda-Alban, Julio
dc.contributor.author Fernandez-Miñope, Carlos
dc.contributor.author Brouwer, Kimberly C.
dc.contributor.author Torres Fajardo, Katherine Jessica
dc.contributor.author Calderón Sánchez, Maritza Mercedes
dc.contributor.author Gamboa Vilela, Dionicia Baziliza
dc.contributor.author Llanos Cuentas, Elmer Alejandro
dc.contributor.author Vinetz, Joseph Michael
dc.date.accessioned 2019-01-25T15:18:36Z
dc.date.available 2019-01-25T15:18:36Z
dc.date.issued 2017
dc.identifier.uri https://hdl.handle.net/20.500.12866/4670
dc.description.abstract BACKGROUND: The incidence of malaria due both to Plasmodium falciparum and Plasmodium vivax in the Peruvian Amazon has risen in the past 5 years. This study tested the hypothesis that the maintenance and emergence of malaria in hypoendemic regions such as Amazonia is determined by submicroscopic and asymptomatic Plasmodium parasitaemia carriers. The present study aimed to precisely quantify the rate of very-low parasitaemia carriers in two sites of the Peruvian Amazon in relation to transmission patterns of P. vivax and P. falciparum in this area. METHODS: This study was carried out within the Amazonian-ICEMR longitudinal cohort. Blood samples were collected for light microscopy diagnosis and packed red blood cell (PRBC) samples were analysed by qPCR. Plasma samples were tested for total IgG reactivity against recombinant PvMSP-10 and PfMSP-10 antigens by ELISA. Occupation and age 10 years and greater were considered surrogates of occupation-related mobility. Risk factors for P. falciparum and P. vivax infections detected by PRBC-qPCR were assessed by multilevel logistic regression models. RESULTS: Among 450 subjects, the prevalence of P. vivax by PRBC-PCR (25.1%) was sixfold higher than that determined by microscopy (3.6%). The prevalence of P. falciparum infection was 4.9% by PRBC-PCR and 0.2% by microscopy. More than 40% of infections had parasitaemia under 5 parasites/μL. Multivariate analysis for infections detected by PRBC-PCR showed that participants with recent settlement in the study area (AOR 2.1; 95% CI 1.03:4.2), age ≥ 30 years (AOR 3.3; 95% CI 1.6:6.9) and seropositivity to P. vivax (AOR 1.8; 95% CI 1.0:3.2) had significantly higher likelihood of P. vivax infection, while the odds of P. falciparum infection was higher for participants between 10 and 29 years (AOR 10.7; 95% CI 1.3:91.1) and with a previous P. falciparum infection (AOR 10.4; 95% CI 1.5:71.1). CONCLUSIONS: This study confirms the contrasting transmission patterns of P. vivax and P. falciparum in the Peruvian Amazon, with stable local transmission for P. vivax and the source of P. falciparum to the study villages dominated by very low parasitaemia carriers, age 10 years and older, who had travelled away from home for work and brought P. falciparum infection with them. en_US
dc.language.iso eng
dc.publisher BioMed Central
dc.relation.ispartofseries Malaria Journal
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Human mobility en_US
dc.subject Malaria en_US
dc.subject Migration en_US
dc.subject Molecular epidemiology en_US
dc.subject MSP10 en_US
dc.subject Plasmodium falciparum en_US
dc.subject Plasmodium vivax en_US
dc.subject Sensitivity en_US
dc.subject Serology en_US
dc.subject Specificity en_US
dc.subject Sub-microscopic en_US
dc.subject Adolescent en_US
dc.subject Adult en_US
dc.subject Asymptomatic Infections/epidemiology en_US
dc.subject Child en_US
dc.subject Cross-Sectional Studies en_US
dc.subject Female en_US
dc.subject Humans en_US
dc.subject Malaria, Falciparum/epidemiology/parasitology en_US
dc.subject Malaria, Vivax/epidemiology/parasitology en_US
dc.subject Male en_US
dc.subject Multivariate Analysis en_US
dc.subject Parasitemia/epidemiology/parasitology en_US
dc.subject Peru/epidemiology en_US
dc.subject Plasmodium falciparum/isolation & purification en_US
dc.subject Plasmodium vivax/isolation & purification en_US
dc.subject Prevalence en_US
dc.subject Seroepidemiologic Studies en_US
dc.subject Young Adult en_US
dc.title High prevalence of very-low Plasmodium falciparum and Plasmodium vivax parasitaemia carriers in the Peruvian Amazon: insights into local and occupational mobility-related transmission en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1186/s12936-017-2063-x
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.07
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.08
dc.relation.issn 1475-2875


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